COPS4

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COPS4

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'''COP9 signalosome complex subunit 4''' is a [[protein]] that in humans is encoded by the ''COPS4'' [[gene]].{{cite journal | vauthors = Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW | title = The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex | journal = Curr Biol | volume = 8 | issue = 16 | pages = 919–924 |date=Oct 1998 | pmid = 9707402 | doi =10.1016/S0960-9822(07)00372-7 | s2cid = 13873982 | doi-access = free | bibcode = 1998CBio....8..919W }}{{cite web | title = Entrez Gene: COPS4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=51138}}
'''COP9 signalosome complex subunit 4''' is a [[protein]] that in humans is encoded by the ''COPS4'' [[gene]].{{cite journal | vauthors = Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW | title = The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex | journal = Curr Biol | volume = 8 | issue = 16 | pages = 919–924 |date=Oct 1998 | pmid = 9707402 | doi =10.1016/S0960-9822(07)00372-7 | s2cid = 13873982 | doi-access = free | bibcode = 1998CBio....8..919W }}{{cite web | title = Entrez Gene: COPS4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=51138}}


This gene encodes one of eight subunits composing [[COP9 signalosome]], a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.
This gene encodes one of eight subunits composing [[COP9 signalosome]], a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S [[proteasome]]. COP9 signalosome has been shown to interact with SCF-type E3 [[ubiquitin]] ligases and act as a positive regulator of E3 ubiquitin ligases.


==References==
==References==
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