Transcranial direct-current stimulation

Transcranial direct-current stimulation

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← Previous revision Revision as of 23:14, 19 April 2026
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There is some evidence tDCS might be of moderate benefit as treatment for mild and moderate [[Depression (mood)|depression]],{{Cite journal |last1=Cheng |first1=Ying-Chih |last2=Kuo |first2=Po-Hsiu |last3=Su |first3=Min-I |last4=Huang |first4=Wei-Lieh |date=2022-04-01 |title=The efficacy of non-invasive, non-convulsive electrical neuromodulation on depression, anxiety and sleep disturbance: a systematic review and meta-analysis |journal=Psychological Medicine |language=en |volume=52 |issue=5 |pages=801–812 |doi=10.1017/S0033291721005560 |issn=0033-2917|doi-access=free |pmid=35105413 }}{{Cite journal |last1=Zheng |first1=Esther Zhiwei |last2=Wong |first2=Nichol M. L. |last3=Yang |first3=Angela S. Y. |last4=Lee |first4=Tatia M. C. |date=2024-07-18 |title=Evaluating the effects of tDCS on depressive and anxiety symptoms from a transdiagnostic perspective: a systematic review and meta-analysis of randomized controlled trials |journal=Translational Psychiatry |language=en |volume=14 |issue=1 |page=295 |doi=10.1038/s41398-024-03003-w |pmid=39025832 |issn=2158-3188|pmc=11258305 }} [[major depressive disorder]]{{cite journal | vauthors = Moffa AH, Martin D, Alonzo A, Bennabi D, Blumberger DM, Benseñor IM, Daskalakis Z, Fregni F, Haffen E, Lisanby SH, Padberg F, Palm U, Razza LB, Sampaio-Jr B, Loo C, Brunoni AR | display-authors = 6 | title = Efficacy and acceptability of transcranial direct current stimulation (tDCS) for major depressive disorder: An individual patient data meta-analysis | journal = Progress in Neuro-Psychopharmacology & Biological Psychiatry | volume = 99 | article-number = 109836 | date = April 2020 | pmid = 31837388 | doi = 10.1016/j.pnpbp.2019.109836 | s2cid = 209373871 | hdl = 1959.4/unsworks_81424 | url = https://unsworks.unsw.edu.au/bitstreams/967e9af1-ae7e-4a90-98f0-7f943f35d83b/download | hdl-access = free }} and [[treatment-resistant depression]].{{Cite journal |last1=Li |first1=John |last2=Kung |first2=Simon |last3=Croarkin |first3=Paul |last4=Lapid |first4=Maria |date=2024-04-01 |title=Transcranial Direct Current Stimulation (tDCS) for Treatment Resistant Depression (TRD): A Systematic Review |url=https://linkinghub.elsevier.com/retrieve/pii/S1064748124001921 |journal=The American Journal of Geriatric Psychiatry |language=en |volume=32 |issue=4 |pages=S99 |doi=10.1016/j.jagp.2024.01.181|url-access=subscription }}
There is some evidence tDCS might be of moderate benefit as treatment for mild and moderate [[Depression (mood)|depression]],{{Cite journal |last1=Cheng |first1=Ying-Chih |last2=Kuo |first2=Po-Hsiu |last3=Su |first3=Min-I |last4=Huang |first4=Wei-Lieh |date=2022-04-01 |title=The efficacy of non-invasive, non-convulsive electrical neuromodulation on depression, anxiety and sleep disturbance: a systematic review and meta-analysis |journal=Psychological Medicine |language=en |volume=52 |issue=5 |pages=801–812 |doi=10.1017/S0033291721005560 |issn=0033-2917|doi-access=free |pmid=35105413 }}{{Cite journal |last1=Zheng |first1=Esther Zhiwei |last2=Wong |first2=Nichol M. L. |last3=Yang |first3=Angela S. Y. |last4=Lee |first4=Tatia M. C. |date=2024-07-18 |title=Evaluating the effects of tDCS on depressive and anxiety symptoms from a transdiagnostic perspective: a systematic review and meta-analysis of randomized controlled trials |journal=Translational Psychiatry |language=en |volume=14 |issue=1 |page=295 |doi=10.1038/s41398-024-03003-w |pmid=39025832 |issn=2158-3188|pmc=11258305 }} [[major depressive disorder]]{{cite journal | vauthors = Moffa AH, Martin D, Alonzo A, Bennabi D, Blumberger DM, Benseñor IM, Daskalakis Z, Fregni F, Haffen E, Lisanby SH, Padberg F, Palm U, Razza LB, Sampaio-Jr B, Loo C, Brunoni AR | display-authors = 6 | title = Efficacy and acceptability of transcranial direct current stimulation (tDCS) for major depressive disorder: An individual patient data meta-analysis | journal = Progress in Neuro-Psychopharmacology & Biological Psychiatry | volume = 99 | article-number = 109836 | date = April 2020 | pmid = 31837388 | doi = 10.1016/j.pnpbp.2019.109836 | s2cid = 209373871 | hdl = 1959.4/unsworks_81424 | url = https://unsworks.unsw.edu.au/bitstreams/967e9af1-ae7e-4a90-98f0-7f943f35d83b/download | hdl-access = free }} and [[treatment-resistant depression]].{{Cite journal |last1=Li |first1=John |last2=Kung |first2=Simon |last3=Croarkin |first3=Paul |last4=Lapid |first4=Maria |date=2024-04-01 |title=Transcranial Direct Current Stimulation (tDCS) for Treatment Resistant Depression (TRD): A Systematic Review |url=https://linkinghub.elsevier.com/retrieve/pii/S1064748124001921 |journal=The American Journal of Geriatric Psychiatry |language=en |volume=32 |issue=4 |pages=S99 |doi=10.1016/j.jagp.2024.01.181|url-access=subscription }}

Recent research has emphasized considerable variability in the effects of transcranial direct current stimulation (tDCS), indicating that its efficacy is not uniform across individuals or experimental conditions. Factors such as baseline neural activity, electrode placement, and stimulation parameters have been shown to significantly influence outcomes, contributing to inconsistent findings across studies


=== Other medical use ===
=== Other medical use ===
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A 2015 review of results from hundreds of tDCS experiments found that there was no statistically conclusive evidence to support any net cognitive effect, positive or negative, of single session tDCS in healthy populations{{snd}}there is no evidence that tDCS is useful for [[Human enhancement|cognitive enhancement]]. A second study by the same authors found there was little-to-no statistically reliable impact of tDCS on any neurophysiologic outcome.
A 2015 review of results from hundreds of tDCS experiments found that there was no statistically conclusive evidence to support any net cognitive effect, positive or negative, of single session tDCS in healthy populations{{snd}}there is no evidence that tDCS is useful for [[Human enhancement|cognitive enhancement]]. A second study by the same authors found there was little-to-no statistically reliable impact of tDCS on any neurophysiologic outcome.
Some meta-analyses have reported little to no reliable cognitive enhancement effects of tDCS in healthy populations, suggesting that previously reported benefits may be inconsistent or influenced by methodological variability


==== Parkinson's, Alzheimer's disease, and schizophrenia ====
==== Parkinson's, Alzheimer's disease, and schizophrenia ====