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'''Small-cell carcinoma''', also known as '''oat cell carcinoma''', is a type of highly aggressive [[cancer]] that most commonly arises within the [[lung]],[{{DorlandsDict|nine/000951105|small-cell carcinoma}}] although it can occasionally arise in other body sites, such as the [[cervix]],[{{cite journal | vauthors = Nasu K, Hirakawa T, Okamoto M, Nishida M, Kiyoshima C, Matsumoto H, Takai N, Narahara H | title = Advanced small cell carcinoma of the uterine cervix treated by neoadjuvant chemotherapy with irinotecan and cisplatin followed by radical surgery | journal = Rare Tumors | volume = 3 | issue = 1 | pages = 18–20 | date = March 2011 | pmid = 21464879 | pmc = 3070456 | doi = 10.4081/rt.2011.e6 }}] [[prostate]],[{{cite journal |vauthors=Nadal R, Schweizer M, Kryvenko ON, Epstein JI, Eisenberger MA |title=Small cell carcinoma of the prostate |journal=Nat Rev Urol |volume=11 |issue=4 |pages=213–9 |date=April 2014 |pmid=24535589 |doi=10.1038/nrurol.2014.21 |url=}}][{{cite journal | vauthors = Capizzello A, Peponi E, Simou N, Ntaskagiannis D, Tasiou I, Kamina S, Tsekeris P | title = Pure small cell carcinoma of the prostate: a case report and literature review | journal = Case Reports in Oncology | volume = 4 | issue = 1 | pages = 88–95 | date = February 2011 | pmid = 21475596 | pmc = 3072185 | doi = 10.1159/000324717 }}] [[bladder]],[{{cite journal |vauthors=Shatagopam K, Kaimakliotis HZ, Cheng L, Koch MO |title=Genitourinary small cell malignancies: prostate and bladder |journal=Future Oncol |volume=11 |issue=3 |pages=479–88 |date=2015 |pmid=25675127 |doi=10.2217/fon.14.277 |url=}}] and [[gastrointestinal tract]]. Compared to [[non-small-cell lung carcinoma|non-small cell carcinoma]], small cell carcinoma is more aggressive, with a shorter doubling time, higher growth fraction, and earlier development of metastases.[{{cite book | vauthors = Basumallik N, Agarwal N | chapter = Small Cell Lung Cancer |date=2023 | chapter-url=https://www.ncbi.nlm.nih.gov/books/NBK482458/ | title = StatPearls |access-date=2023-10-02 |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=29494065 }}] |
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'''Small-cell carcinoma''', is a type of highly aggressive [[cancer]] that most commonly arises within the [[lung]],[{{DorlandsDict|nine/000951105|small-cell carcinoma}}] although it can occasionally arise in other body sites, such as the [[cervix]],[{{cite journal | vauthors = Nasu K, Hirakawa T, Okamoto M, Nishida M, Kiyoshima C, Matsumoto H, Takai N, Narahara H | title = Advanced small cell carcinoma of the uterine cervix treated by neoadjuvant chemotherapy with irinotecan and cisplatin followed by radical surgery | journal = Rare Tumors | volume = 3 | issue = 1 | pages = 18–20 | date = March 2011 | pmid = 21464879 | pmc = 3070456 | doi = 10.4081/rt.2011.e6 }}] [[prostate]],[{{cite journal |vauthors=Nadal R, Schweizer M, Kryvenko ON, Epstein JI, Eisenberger MA |title=Small cell carcinoma of the prostate |journal=Nat Rev Urol |volume=11 |issue=4 |pages=213–9 |date=April 2014 |pmid=24535589 |doi=10.1038/nrurol.2014.21 |url=}}][{{cite journal | vauthors = Capizzello A, Peponi E, Simou N, Ntaskagiannis D, Tasiou I, Kamina S, Tsekeris P | title = Pure small cell carcinoma of the prostate: a case report and literature review | journal = Case Reports in Oncology | volume = 4 | issue = 1 | pages = 88–95 | date = February 2011 | pmid = 21475596 | pmc = 3072185 | doi = 10.1159/000324717 }}] [[bladder]],[{{cite journal |vauthors=Shatagopam K, Kaimakliotis HZ, Cheng L, Koch MO |title=Genitourinary small cell malignancies: prostate and bladder |journal=Future Oncol |volume=11 |issue=3 |pages=479–88 |date=2015 |pmid=25675127 |doi=10.2217/fon.14.277 |url=}}] and [[gastrointestinal tract]]. Compared to [[non-small-cell lung carcinoma|non-small cell carcinoma]], small cell carcinoma is more aggressive, with a shorter doubling time, higher growth fraction, and earlier development of metastases.[{{cite book | vauthors = Basumallik N, Agarwal N | chapter = Small Cell Lung Cancer |date=2023 | chapter-url=https://www.ncbi.nlm.nih.gov/books/NBK482458/ | title = StatPearls |access-date=2023-10-02 |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=29494065 }}] |
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Small-cell carcinoma is a [[neuroendocrine tumor]], meaning that the cells were originally part of the [[Neuroendocrinology|neuroendocrine system]]. As a result, small cell carcinomas often secrete various [[hormone]]s, such as [[adrenocorticotropic hormone]] or [[vasopressin]]. The unpredictable hormone secretion of small-cell carcinoma adds additional symptoms and mortality to the aggressive course of the cancer.[{{Cite journal |last1=Megyesfalvi |first1=Zsolt |last2=Gay |first2=Carl M. |last3=Popper |first3=Helmut |last4=Pirker |first4=Robert |last5=Ostoros |first5=Gyula |last6=Heeke |first6=Simon |last7=Lang |first7=Christian |last8=Hoetzenecker |first8=Konrad |last9=Schwendenwein |first9=Anna |last10=Boettiger |first10=Kristiina |last11=Bunn jr |first11=Paul A. |last12=Renyi-Vamos |first12=Ferenc |last13=Schelch |first13=Karin |last14=Prosch |first14=Helmut |last15=Byers |first15=Lauren A. |date=2023 |title=Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions |url=https://onlinelibrary.wiley.com/doi/abs/10.3322/caac.21785 |journal=CA: A Cancer Journal for Clinicians |language=en |volume=73 |issue=6 |pages=620–652 |doi=10.3322/caac.21785 |pmid=37329269 |issn=1542-4863}}] |
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Small-cell carcinoma is a [[neuroendocrine tumor]], meaning that the cells were originally part of the [[Neuroendocrinology|neuroendocrine system]]. As a result, small cell carcinomas often secrete various [[hormone]]s, such as [[adrenocorticotropic hormone]] or [[vasopressin]]. The unpredictable hormone secretion of small-cell carcinoma adds additional symptoms and mortality to the aggressive course of the cancer.[{{Cite journal |last1=Megyesfalvi |first1=Zsolt |last2=Gay |first2=Carl M. |last3=Popper |first3=Helmut |last4=Pirker |first4=Robert |last5=Ostoros |first5=Gyula |last6=Heeke |first6=Simon |last7=Lang |first7=Christian |last8=Hoetzenecker |first8=Konrad |last9=Schwendenwein |first9=Anna |last10=Boettiger |first10=Kristiina |last11=Bunn jr |first11=Paul A. |last12=Renyi-Vamos |first12=Ferenc |last13=Schelch |first13=Karin |last14=Prosch |first14=Helmut |last15=Byers |first15=Lauren A. |date=2023 |title=Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions |url=https://onlinelibrary.wiley.com/doi/abs/10.3322/caac.21785 |journal=CA: A Cancer Journal for Clinicians |language=en |volume=73 |issue=6 |pages=620–652 |doi=10.3322/caac.21785 |pmid=37329269 |issn=1542-4863}}] |
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