Para-Chlorophenethylamine

''Para''-chlorophenethylamine acts primarily as a [[Serotonin releasing agent|serotonin-releasing agent]] with an {{Abbrlink|EC₅₀|Half maximal effective concentration}} value of 430 nM for the [[serotonin transporter]], approximately the dose required to induce [[serotonin syndrome]] with [[Seizure|seizures]], [[tremor]], and [[hyperthermia]] in mice, is quite low compared to other derivatives (such as ''ortho''-chlorophenethylamine and ''meta-''chlorophenethylamine){{Cite journal |last=Chung Hwang |first=E. |last2=Van Woert |first2=M. H. |date= |title=Comparative effects of substituted phenylethylamines on brain serotonergic mechanisms |url=https://pubmed.ncbi.nlm.nih.gov/6965983 |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=213 |issue=2 |pages=254–260 |issn=0022-3565 |pmid=6965983}}{{Cite journal |last=Eunyong Chung Hwang |last2=Van Woert |first2=Melvin H. |date=1980-12-01 |title=Comparative effects of various serotonin releasing agents in mice |url=https://www.sciencedirect.com/science/article/pii/0006295280905808 |journal=Biochemical Pharmacology |volume=29 |issue=23 |pages=3163–3167 |doi=10.1016/0006-2952(80)90580-8 |issn=0006-2952}} In mice with serotonin syndrome induced by para-chlorophenethylamine, the following [[Signs and symptoms|symptoms]] were observed: lateral head bobbing, a Straub tail reaction, abduction of the [[Hindlimb|hind limbs]], tremors, [[hyperactivity]], mutual pawing with the front paws, [[Saliva|salivation]], and [[Goose bumps|piloerection]].{{Cite journal |last=Hwang |first=Eunyong Chung |last2=Van Woert |first2=Melvin H. |date=1979-02-12 |title=Behavioral and biochemical actions of p-chlorophenylethylamine (p-CPEA) in mice |url=https://www.sciencedirect.com/science/article/pii/0024320579901553 |journal=Life Sciences |volume=24 |issue=7 |pages=595–601 |doi=10.1016/0024-3205(79)90155-3 |issn=0024-3205}}

''Para''-chlorophenethylamine acts primarily as a [[Serotonin releasing agent|serotonin-releasing agent]] with an {{Abbrlink|EC₅₀|Half maximal effective concentration}} value of 430 nM for the [[serotonin transporter]], approximately the dose required to induce [[serotonin syndrome]] with [[Seizure|seizures]], [[tremor]], and [[hyperthermia]] in mice, is quite low compared to other derivatives (such as ''ortho''-chlorophenethylamine and ''meta-''chlorophenethylamine){{Cite journal |last=Chung Hwang |first=E. |last2=Van Woert |first2=M. H. |date= |title=Comparative effects of substituted phenylethylamines on brain serotonergic mechanisms |url=https://pubmed.ncbi.nlm.nih.gov/6965983 |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=213 |issue=2 |pages=254–260 |issn=0022-3565 |pmid=6965983}}{{Cite journal |last=Eunyong Chung Hwang |last2=Van Woert |first2=Melvin H. |date=1980-12-01 |title=Comparative effects of various serotonin releasing agents in mice |url=https://www.sciencedirect.com/science/article/pii/0006295280905808 |journal=Biochemical Pharmacology |volume=29 |issue=23 |pages=3163–3167 |doi=10.1016/0006-2952(80)90580-8 |issn=0006-2952}} In mice with serotonin syndrome induced by para-chlorophenethylamine, the following [[Signs and symptoms|symptoms]] were observed: lateral head bobbing, a Straub tail reaction, abduction of the [[Hindlimb|hind limbs]], tremors, [[hyperactivity]], mutual pawing with the front paws, [[Saliva|salivation]], and [[Goose bumps|piloerection]].{{Cite journal |last=Hwang |first=Eunyong Chung |last2=Van Woert |first2=Melvin H. |date=1979-02-12 |title=Behavioral and biochemical actions of p-chlorophenylethylamine (p-CPEA) in mice |url=https://www.sciencedirect.com/science/article/pii/0024320579901553 |journal=Life Sciences |volume=24 |issue=7 |pages=595–601 |doi=10.1016/0024-3205(79)90155-3 |issn=0024-3205}}

''[[In vitro]]'', it [[Inhibitor (biology)|inhibited]] the activity of the [[enzyme]] [[phenylethanolamine N-methyltransferase]].{{Cite journal |last=Coen |first=C. W. |last2=Coombs |first2=M. C. |last3=Wilson |first3=P. M. |last4=Clement |first4=E. M. |last5=MacKinnon |first5=P. C. |date= |title=Possible resolution of a paradox concerning the use of p-chlorophenylalanine and 5-hydroxytryptophan: evidence for a mode of action involving adrenaline in manipulating the surge of luteinizing hormone in rats |url=https://pubmed.ncbi.nlm.nih.gov/6222267 |journal=Neuroscience |volume=8 |issue=3 |pages=583–591 |doi=10.1016/0306-4522(83)90200-2 |issn=0306-4522 |pmid=6222267}} ''Para''-chlorophenelethylamine stimulated [[5-HT receptor|5-HT receptors]].

''[[In vitro]]'', it [[Inhibitor (biology)|inhibited]] the activity of the [[enzyme]] [[phenylethanolamine N-methyltransferase]].{{Cite journal |last=Coen |first=C. W. |last2=Coombs |first2=M. C. |last3=Wilson |first3=P. M. |last4=Clement |first4=E. M. |last5=MacKinnon |first5=P. C. |date= |title=Possible resolution of a paradox concerning the use of p-chlorophenylalanine and 5-hydroxytryptophan: evidence for a mode of action involving adrenaline in manipulating the surge of luteinizing hormone in rats |url=https://pubmed.ncbi.nlm.nih.gov/6222267 |journal=Neuroscience |volume=8 |issue=3 |pages=583–591 |doi=10.1016/0306-4522(83)90200-2 |issn=0306-4522 |pmid=6222267}} ''Para''-chlorophenelethylamine stimulated [[5-HT receptor|5-HT receptors]].>{{Cite journal |last=Sloviter |first=Robert S. |last2=Connor |first2=John D. |last3=Dimaano |first3=Bruce P. |last4=Drust |first4=Eugene G. |date=1980-08-01 |title=Para-halogenated phenethylamines: Similar serotonergic effects in rats by different mechanisms |url=https://www.sciencedirect.com/science/article/pii/0091305780900842 |journal=Pharmacology Biochemistry and Behavior |volume=13 |issue=2 |pages=283–286 |doi=10.1016/0091-3057(80)90084-2 |issn=0091-3057}}>

=== Pharmacokinetics ===

=== Pharmacokinetics ===