Iain McInnes

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Iain McInnes

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'''Iain Blair McInnes''' {{Post-nominals|country=GBR|size=100%CBE|FRCPE|FRCPGlas|FMedSci|FRSE}} (born 19 October 1964) is a Scottish [[Rheumatology|rheumatologist]], Vice Principal and Head of the College of Medical, Veterinary and Life Sciences, Muirhead Chair of Medicine and Versus Arthritis Professor of Rheumatology at the [[University of Glasgow]]. His research has focused on [[inflammatory diseases]], particularly [[rheumatoid arthritis]] and [[psoriatic arthritis]].{{Cite web|url=https://www.gla.ac.uk/research/beacons/precisionmedicine/professoriainmcinnes/|title=University of Glasgow - Research - Glasgow Research Beacons - Precision Medicine & Chronic Diseases - Professor Iain McInnes|website=www.gla.ac.uk|access-date=12 March 2024|archive-date=3 May 2024|archive-url=https://web.archive.org/web/20240503105149/https://www.gla.ac.uk/research/beacons/precisionmedicine/professoriainmcinnes/|url-status=dead}}
'''Iain Blair McInnes''' {{Post-nominals|country=GBR|size=100%CBE|FRCPE|FRCPGlas|FMedSci|FRSE}} (born 19 October 1964) is a Scottish [[Rheumatology|rheumatologist]], Vice Principal and Head of the College of Medical, Veterinary and Life Sciences, Muirhead Chair of Medicine and Versus Arthritis Professor of Rheumatology at the [[University of Glasgow]]. name="positioncitation">{{Cite web|url=https://www.medpagetoday.com/reading-room/aad/psoriasis/105580|title=AAD Reading Room | Iain McInnes, MD, on the Latest Findings on Bimekizumab for Psoriatic Arthritis | MedPage Today}} His research has focused on [[inflammatory diseases]], particularly [[rheumatoid arthritis]] and [[psoriatic arthritis]].{{Cite web|url=https://www.gla.ac.uk/research/beacons/precisionmedicine/professoriainmcinnes/|title=University of Glasgow - Research - Glasgow Research Beacons - Precision Medicine & Chronic Diseases - Professor Iain McInnes|website=www.gla.ac.uk|access-date=12 March 2024|archive-date=3 May 2024|archive-url=https://web.archive.org/web/20240503105149/https://www.gla.ac.uk/research/beacons/precisionmedicine/professoriainmcinnes/|url-status=dead}}


His work has focused on new approaches and treatments for inflammatory diseases. Over two decades, he has been involved in clinical trials and pathogenesis investigation programs in [[inflammatory arthritis]] at an international level. His research has also explored the biology of inflammatory cytokines in arthritis and other inflammatory diseases, as well as the mechanisms of co-morbidities in chronic diseases.{{Cite web|url=https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/fellow/Professor-Iain-McInnes-0015437|title=Professor Iain McInnes|website=acmedsci.ac.uk}}
His work has focused on new approaches and treatments for inflammatory diseases. Over two decades, he has been involved in clinical trials and pathogenesis investigation programs in [[inflammatory arthritis]] at an international level. His research has also explored the biology of inflammatory cytokines in arthritis and other inflammatory diseases, as well as the mechanisms of co-morbidities in chronic diseases.{{Cite web|url=https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/fellow/Professor-Iain-McInnes-0015437|title=Professor Iain McInnes|website=acmedsci.ac.uk}}
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==Research==
==Research==


McInnes's research has investigated the role of cytokines and their inflammation amplification role in immune-mediated inflammatory disease (IMID) pathogenesis. His early work focused on defining the roles played by novel cytokines in driving inflammatory synovitis, including the effector functions of IL-15, IL-18, and IL-33 in rheumatoid (RA) and psoriatic arthritis (PsA) synovitis.{{cite journal | pmid=9018238 | date=1997 | last1=McInnes | first1=I. B. | last2=Leung | first2=B. P. | last3=Sturrock | first3=R. D. | last4=Field | first4=M. | last5=Liew | first5=F. Y. | title=Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis | journal=Nature Medicine | volume=3 | issue=2 | pages=189–195 | doi=10.1038/nm0297-189 }}{{cite journal | pmid=10562301 | date=1999 | last1=Gracie | first1=J. A. | last2=Forsey | first2=R. J. | last3=Chan | first3=W. L. | last4=Gilmour | first4=A. | last5=Leung | first5=B. P. | last6=Greer | first6=M. R. | last7=Kennedy | first7=K. | last8=Carter | first8=R. | last9=Wei | first9=X. Q. | last10=Xu | first10=D. | last11=Field | first11=M. | last12=Foulis | first12=A. | last13=Liew | first13=F. Y. | last14=McInnes | first14=I. B. | title=A proinflammatory role for IL-18 in rheumatoid arthritis | journal=The Journal of Clinical Investigation | volume=104 | issue=10 | pages=1393–1701 | doi=10.1172/JCI7317 | pmc=409841 }}{{cite journal | pmid=20139274 | date=2010 | last1=Xu | first1=D. | last2=Jiang | first2=H. R. | last3=Li | first3=Y. | last4=Pushparaj | first4=P. N. | last5=Kurowska-Stolarska | first5=M. | last6=Leung | first6=B. P. | last7=Mu | first7=R. | last8=Tay | first8=H. K. | last9=McKenzie | first9=A. N. | last10=McInnes | first10=I. B. | last11=Melendez | first11=A. J. | last12=Liew | first12=F. Y. | title=IL-33 exacerbates autoantibody-induced arthritis | journal=Journal of Immunology | volume=184 | issue=5 | pages=2620–2626 | doi=10.4049/jimmunol.0902685 }} His studies also examined the cytokine-driven cellular interactions between T cells, macrophages, and synovial fibroblasts, particularly the role of non-antigen dependent amplification of synovial inflammation.{{cite journal | pmid=11094451 | date=2000 | last1=McInnes | first1=I. B. | last2=Leung | first2=B. P. | last3=Liew | first3=F. Y. | title=Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells | journal=Arthritis Research | volume=2 | issue=5 | pages=374–378 | doi=10.1186/ar115 | doi-access=free | pmc=130139 }}{{cite journal | url=https://www.nature.com/articles/nri2094#:~:text=Cytokines%20are%20implicated%20in%20each,destruction%20of%20adjacent%20joint%20tissue | doi=10.1038/nri2094 | title=Cytokines in the pathogenesis of rheumatoid arthritis | date=2007 | last1=McInnes | first1=Iain B. | last2=Schett | first2=Georg | journal=Nature Reviews Immunology | volume=7 | issue=6 | pages=429–442 | pmid=17525752 | url-access=subscription }}
McInnes's research has investigated the role of [[Cytokine|cytokines]] and their inflammation amplification role in immune-mediated inflammatory disease (IMID) pathogenesis. His early work focused on defining the roles played by novel cytokines in driving [[synovitis]], including the effector functions of [[IL-15 receptor|IL-15,]] [[IL-18 receptor|IL-18]], and [[IL-33]] in rheumatoid (RA) and psoriatic arthritis (PsA) synovitis.{{cite journal | pmid=9018238 | date=1997 | last1=McInnes | first1=I. B. | last2=Leung | first2=B. P. | last3=Sturrock | first3=R. D. | last4=Field | first4=M. | last5=Liew | first5=F. Y. | title=Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis | journal=Nature Medicine | volume=3 | issue=2 | pages=189–195 | doi=10.1038/nm0297-189 }}{{cite journal | pmid=10562301 | date=1999 | last1=Gracie | first1=J. A. | last2=Forsey | first2=R. J. | last3=Chan | first3=W. L. | last4=Gilmour | first4=A. | last5=Leung | first5=B. P. | last6=Greer | first6=M. R. | last7=Kennedy | first7=K. | last8=Carter | first8=R. | last9=Wei | first9=X. Q. | last10=Xu | first10=D. | last11=Field | first11=M. | last12=Foulis | first12=A. | last13=Liew | first13=F. Y. | last14=McInnes | first14=I. B. | title=A proinflammatory role for IL-18 in rheumatoid arthritis | journal=The Journal of Clinical Investigation | volume=104 | issue=10 | pages=1393–1701 | doi=10.1172/JCI7317 | pmc=409841 }}{{cite journal | pmid=20139274 | date=2010 | last1=Xu | first1=D. | last2=Jiang | first2=H. R. | last3=Li | first3=Y. | last4=Pushparaj | first4=P. N. | last5=Kurowska-Stolarska | first5=M. | last6=Leung | first6=B. P. | last7=Mu | first7=R. | last8=Tay | first8=H. K. | last9=McKenzie | first9=A. N. | last10=McInnes | first10=I. B. | last11=Melendez | first11=A. J. | last12=Liew | first12=F. Y. | title=IL-33 exacerbates autoantibody-induced arthritis | journal=Journal of Immunology | volume=184 | issue=5 | pages=2620–2626 | doi=10.4049/jimmunol.0902685 }} His studies also examined the cytokine-driven cellular interactions between T cells, macrophages, and [[Fibroblast|synovial fibroblasts]], particularly the role of non-antigen dependent amplification of synovial inflammation.{{cite journal | pmid=11094451 | date=2000 | last1=McInnes | first1=I. B. | last2=Leung | first2=B. P. | last3=Liew | first3=F. Y. | title=Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells | journal=Arthritis Research | volume=2 | issue=5 | pages=374–378 | doi=10.1186/ar115 | doi-access=free | pmc=130139 }}{{cite journal | url=https://www.nature.com/articles/nri2094#:~:text=Cytokines%20are%20implicated%20in%20each,destruction%20of%20adjacent%20joint%20tissue | doi=10.1038/nri2094 | title=Cytokines in the pathogenesis of rheumatoid arthritis | date=2007 | last1=McInnes | first1=Iain B. | last2=Schett | first2=Georg | journal=Nature Reviews Immunology | volume=7 | issue=6 | pages=429–442 | pmid=17525752 | url-access=subscription }}


Subsequently, his research identified several novel synovial [[cytokine]] amplificatory pathways involved in disease chronicity, such as PAR2 dependent matrix enzyme sensing,{{cite journal | url=https://ard.bmj.com/content/71/6/1049 | pmid=22294633 | date=2012 | last1=Crilly | first1=A. | last2=Burns | first2=E. | last3=Nickdel | first3=M. B. | last4=Lockhart | first4=J. C. | last5=Perry | first5=M. E. | last6=Ferrell | first6=P. W. | last7=Baxter | first7=D. | last8=Dale | first8=J. | last9=Dunning | first9=L. | last10=Wilson | first10=H. | last11=Nijjar | first11=J. S. | last12=Gracie | first12=J. A. | last13=Ferrell | first13=W. R. | last14=McInnes | first14=I. B. | title=PAR(2) expression in peripheral blood monocytes of patients with rheumatoid arthritis | journal=Annals of the Rheumatic Diseases | volume=71 | issue=6 | pages=1049–1054 | doi=10.1136/annrheumdis-2011-200703 | pmc=4861243 }} and autoantibody to MICL mediated [[monocyte]] activation.{{cite journal | url=https://ard.bmj.com/content/75/7/1386 | pmid=26275430 | doi=10.1136/annrheumdis-2014-206644 | title=MICL controls inflammation in rheumatoid arthritis | date=2016 | last1=Redelinghuys | first1=Pierre | last2=Whitehead | first2=Lauren | last3=Augello | first3=Andrea | last4=Drummond | first4=Rebecca A. | last5=Levesque | first5=Jean-Michel | last6=Vautier | first6=Simon | last7=Reid | first7=Delyth M. | last8=Kerscher | first8=Bernhard | last9=Taylor | first9=Julie A. | last10=Nigrovic | first10=Peter A. | last11=Wright | first11=John | last12=Murray | first12=Graeme I. | last13=Willment | first13=Janet A. | last14=Hocking | first14=Lynne J. | last15=Fernandes | first15=Maria J G. | last16=De Bari | first16=Cosimo | last17=McInnes | first17=Iain B. | last18=Brown | first18=Gordon D. | journal=Annals of the Rheumatic Diseases | volume=75 | issue=7 | pages=1386–1391 | pmc=4941174 }} These studies have contributed to the understanding of the cellular and molecular mechanisms underlying inflammatory synovial disease.{{cite web | url=https://scholar.google.com/citations?user=BQAh1-UAAAAJ&hl=en | title=I McInnes }}
Subsequently, his research identified several novel synovial cytokine amplificatory pathways involved in disease chronicity, such as [[PAR-2]] dependent matrix enzyme sensing,{{cite journal | url=https://ard.bmj.com/content/71/6/1049 | pmid=22294633 | date=2012 | last1=Crilly | first1=A. | last2=Burns | first2=E. | last3=Nickdel | first3=M. B. | last4=Lockhart | first4=J. C. | last5=Perry | first5=M. E. | last6=Ferrell | first6=P. W. | last7=Baxter | first7=D. | last8=Dale | first8=J. | last9=Dunning | first9=L. | last10=Wilson | first10=H. | last11=Nijjar | first11=J. S. | last12=Gracie | first12=J. A. | last13=Ferrell | first13=W. R. | last14=McInnes | first14=I. B. | title=PAR(2) expression in peripheral blood monocytes of patients with rheumatoid arthritis | journal=Annals of the Rheumatic Diseases | volume=71 | issue=6 | pages=1049–1054 | doi=10.1136/annrheumdis-2011-200703 | pmc=4861243 }} and autoantibody to [[MICL]]-mediated [[monocyte]] activation.{{cite journal | url=https://ard.bmj.com/content/75/7/1386 | pmid=26275430 | doi=10.1136/annrheumdis-2014-206644 | title=MICL controls inflammation in rheumatoid arthritis | date=2016 | last1=Redelinghuys | first1=Pierre | last2=Whitehead | first2=Lauren | last3=Augello | first3=Andrea | last4=Drummond | first4=Rebecca A. | last5=Levesque | first5=Jean-Michel | last6=Vautier | first6=Simon | last7=Reid | first7=Delyth M. | last8=Kerscher | first8=Bernhard | last9=Taylor | first9=Julie A. | last10=Nigrovic | first10=Peter A. | last11=Wright | first11=John | last12=Murray | first12=Graeme I. | last13=Willment | first13=Janet A. | last14=Hocking | first14=Lynne J. | last15=Fernandes | first15=Maria J G. | last16=De Bari | first16=Cosimo | last17=McInnes | first17=Iain B. | last18=Brown | first18=Gordon D. | journal=Annals of the Rheumatic Diseases | volume=75 | issue=7 | pages=1386–1391 | pmc=4941174 }} These studies have contributed to the understanding of the cellular and molecular mechanisms underlying inflammatory synovial disease.{{cite web | url=https://scholar.google.com/citations?user=BQAh1-UAAAAJ&hl=en | title=I McInnes }}


==Roles==
==Roles==


⚫
Currently Vice Principal and Head of the College of Medical, Veterinary and Life Sciences, Muirhead Chair of Medicine and Versus Arthritis Professor of Rheumatology at the University of Glasgow, he was past Chairman of the FOREUM (Foundation for European Rheumatology Research) Scientific Committee. From 2019 to 2021, he was President of [[EULAR]],{{cite web | url=https://trasd.org.tr/haber/eular-message-from-the-president-professor-iain-mcinnes | title=EULAR Message from the President, Professor Iain McInnes | Türkiye Romatizma Araştırma ve Savaş Derneği }} the leading transnational society for rheumatology across Europe, during which time he founded the European Rheumatology Research Centre,{{cite journal | url=https://rmdopen.bmj.com/content/8/2/e002456 | pmid=35714997 | doi=10.1136/rmdopen-2022-002456 | title=Levelling the playing field of RMD research across Europe to address patients' needs: The emerging EULAR Research Centre | date=2022 | last1=Reuter | first1=Katja | last2=Haupt | first2=Carina | last3=Molto | first3=Anna | last4=Cope | first4=Andrew | last5=Van Vollenhoven | first5=Ronald F. | last6=Elewaut | first6=Dirk | last7=Lories | first7=Rik | last8=McInnes | first8=Iain B. | journal=RMD Open | volume=8 | issue=2 | article-number=e002456 | pmc=9207999 }} and established pan-European COVID-19 registries to define SARS-CoV-2 risk and vaccine efficacy across IMIDs. He chaired the UK Government's Independent Advisory Group for strategies to support immune vulnerable patient groups during the COVID-19 pandemic.{{cite web | url=https://www.gov.uk/government/publications/higher-risk-patients-eligible-for-covid-19-treatments-independent-advisory-group-report/defining-the-highest-risk-clinical-subgroups-upon-community-infection-with-sars-cov-2-when-considering-the-use-of-neutralising-monoclonal-antibodies | title=Defining the highest-risk clinical subgroups upon community infection with SARS-CoV-2 when considering the use of neutralising monoclonal antibodies (NMABs) and antiviral drugs: Independent advisory group report }}
McInnes is Vice Principal and Head of the College of Medical, Veterinary and Life Sciences, Muirhead Chair of Medicine and Versus Arthritis Professor of Rheumatology at the University of Glasgow.{{Cite web|url=https://www.medpagetoday.com/reading-room/aad/psoriasis/105580|title=AAD Reading Room | Iain McInnes, MD, on the Latest Findings on Bimekizumab for Psoriatic Arthritis | MedPage Today}}

⚫
He is past Chairman of the FOREUM (Foundation for European Rheumatology Research) Scientific Committee. From 2019 to 2021, he was President of [[EULAR]],{{cite web | url=https://trasd.org.tr/haber/eular-message-from-the-president-professor-iain-mcinnes | title=EULAR Message from the President, Professor Iain McInnes | Türkiye Romatizma Araştırma ve Savaş Derneği }} the leading transnational society for rheumatology across Europe, during which time he founded the European Rheumatology Research Centre,{{cite journal | url=https://rmdopen.bmj.com/content/8/2/e002456 | pmid=35714997 | doi=10.1136/rmdopen-2022-002456 | title=Levelling the playing field of RMD research across Europe to address patients' needs: The emerging EULAR Research Centre | date=2022 | last1=Reuter | first1=Katja | last2=Haupt | first2=Carina | last3=Molto | first3=Anna | last4=Cope | first4=Andrew | last5=Van Vollenhoven | first5=Ronald F. | last6=Elewaut | first6=Dirk | last7=Lories | first7=Rik | last8=McInnes | first8=Iain B. | journal=RMD Open | volume=8 | issue=2 | article-number=e002456 | pmc=9207999 }} and established pan-European COVID-19 registries to define SARS-CoV-2 risk and vaccine efficacy across IMIDs. He chaired the UK Government's Independent Advisory Group for strategies to support immune vulnerable patient groups during the COVID-19 pandemic.{{cite web | url=https://www.gov.uk/government/publications/higher-risk-patients-eligible-for-covid-19-treatments-independent-advisory-group-report/defining-the-highest-risk-clinical-subgroups-upon-community-infection-with-sars-cov-2-when-considering-the-use-of-neutralising-monoclonal-antibodies | title=Defining the highest-risk clinical subgroups upon community infection with SARS-CoV-2 when considering the use of neutralising monoclonal antibodies (NMABs) and antiviral drugs: Independent advisory group report }}


He is Director of the Versus Arthritis Centre of Excellence for Inflammatory Arthritis, led from Glasgow and including Universities of Oxford, Newcastle, and Birmingham.{{cite web | url=https://www.heraldscotland.com/news/13147270.determined-doctors-quest-inspired-patients-battles/ | title=Determined doctor's quest is inspired by patients' battles | date=24 February 2014 }} He was Chief Investigator of the IMID-Bio-UK meta-consortium leading the UK effort to discover precision medicine tractable biomarkers for application in immune diseases.{{cite web | url=https://www.manchester.ac.uk/discover/news/universities-to-create--worlds-largest-inflammatory-disease-biobank/ | title=Universities to create world's largest inflammatory disease biobank }}
He is Director of the Versus Arthritis Centre of Excellence for Inflammatory Arthritis, led from Glasgow and including Universities of Oxford, Newcastle, and Birmingham.{{cite web | url=https://www.heraldscotland.com/news/13147270.determined-doctors-quest-inspired-patients-battles/ | title=Determined doctor's quest is inspired by patients' battles | date=24 February 2014 }} He was Chief Investigator of the IMID-Bio-UK meta-consortium leading the UK effort to discover precision medicine tractable biomarkers for application in immune diseases.{{cite web | url=https://www.manchester.ac.uk/discover/news/universities-to-create--worlds-largest-inflammatory-disease-biobank/ | title=Universities to create world's largest inflammatory disease biobank }}
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