Draft:N2G mouse
link NOD mice
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The '''N2G mouse''' ('''N'''OD–'''2'''–'''G'''enes knockout) is a severely [[immunodeficiency|immunodeficient]] laboratory mouse strain developed on a [[ |
The '''N2G mouse''' ('''N'''OD–'''2'''–'''G'''enes knockout) is a severely [[immunodeficiency|immunodeficient]] laboratory mouse strain developed on a [[NOD mice|NOD]] background. The strain was generated by GEMCRO Inc. (South Korea) using [[CRISPR/Cas9]] to delete large genomic regions of ''[[PRKDC|Prkdc]]'', which encodes [[DNA-PKcs|DNA-dependent protein kinase catalytic subunit (DNA-PKcs)]], and ''[[IL2RG|Il2rg]]'', which encodes the [[interleukin-2 receptor]] common gamma chain (γc).{{sfn|Kim|2025}} |
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== Genetics and immunophenotype == |
== Genetics and immunophenotype == |
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