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In humans, tolerance to the anticonvulsant effects of clobazam may occur[{{cite journal | vauthors = Loiseau P | title = [Benzodiazepines in the treatment of epilepsy] | journal = L'Encéphale | volume = 9 | issue = 4 Suppl 2 | pages = 287B–292B | year = 1983 | pmid = 6373234 }}] and withdrawal seizures may occur during abrupt or over-rapid withdrawal.[{{cite journal | vauthors = Robertson MM | title = Current status of the 1,4- and 1,5-benzodiazepines in the treatment of epilepsy: the place of clobazam | journal = Epilepsia | volume = 27 | pages = S27-41 | year = 1986 | issue = Suppl 1 | pmid = 3527689 | doi = 10.1111/j.1528-1157.1986.tb05730.x | s2cid = 23166797 }}] |
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In humans, tolerance to the anticonvulsant effects of clobazam may occur[{{cite journal | vauthors = Loiseau P | title = [Benzodiazepines in the treatment of epilepsy] | journal = L'Encéphale | volume = 9 | issue = 4 Suppl 2 | pages = 287B–292B | year = 1983 | pmid = 6373234 }}] and withdrawal seizures may occur during abrupt or over-rapid withdrawal.[{{cite journal | vauthors = Robertson MM | title = Current status of the 1,4- and 1,5-benzodiazepines in the treatment of epilepsy: the place of clobazam | journal = Epilepsia | volume = 27 | pages = S27-41 | year = 1986 | issue = Suppl 1 | pmid = 3527689 | doi = 10.1111/j.1528-1157.1986.tb05730.x | s2cid = 23166797 }}] |
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Clobazam as with other [[benzodiazepine]] drugs can lead to [[physical dependence]], [[Substance dependence|addiction]], and what is known as the [[benzodiazepine withdrawal syndrome]]. Withdrawal from clobazam or other benzodiazepines after regular use often leads to withdrawal symptoms which are similar to those seen during alcohol and [[barbiturate]] withdrawal. The higher the dosage and the longer the drug is taken, the greater the risk of experiencing unpleasant withdrawal symptoms. Benzodiazepine treatment should only be discontinued via a slow and gradual dose reduction regimen.[{{cite journal | vauthors = MacKinnon GL, Parker WA | title = Benzodiazepine withdrawal syndrome: a literature review and evaluation | journal = The American Journal of Drug and Alcohol Abuse | volume = 9 | issue = 1 | pages = 19–33 | year = 1982 | pmid = 6133446 | doi = 10.3109/00952998209002608 }}] |
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Clobazam as with other [[benzodiazepine]] drugs can lead to [[physical dependence]], [[Substance dependence|addiction]], and what is known as the [[benzodiazepine withdrawal syndrome]]. Withdrawal from clobazam or other benzodiazepines after regular use often leads to withdrawal symptoms which are similar to those seen during [[alcohol]] and [[barbiturate]] withdrawal. The higher the dosage and the longer the drug is taken, the greater the risk of experiencing unpleasant withdrawal symptoms. Benzodiazepine treatment should only be discontinued via a slow and gradual dose reduction regimen.[{{cite journal | vauthors = MacKinnon GL, Parker WA | title = Benzodiazepine withdrawal syndrome: a literature review and evaluation | journal = The American Journal of Drug and Alcohol Abuse | volume = 9 | issue = 1 | pages = 19–33 | year = 1982 | pmid = 6133446 | doi = 10.3109/00952998209002608 }}] |
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