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Karle was the first woman to receive the Bower Award for the Advancement of Science, Franklin Institute in 1993.[{{]Cite book |last=Hargittai |first=Magdolna |title=The Posthumous Nobel Prize in Chemistry. Volume 2. Ladies in Waiting for the Nobel Prize |date=December 14, 2018 |publisher=American Chemical Society |year=2018 |isbn=9780841233911 |pages=1-32}} |
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Karle was the first woman to receive the Bower Award for the Advancement of Science, Franklin Institute in 1993.[{{cite book | last=Hargittai | first=Magdolna | chapter=Women Scientists: An Uphill Battle for Recognition |title=The Posthumous Nobel Prize in Chemistry. Volume 2. Ladies in Waiting for the Nobel Prize| publisher=American Chemical Society | publication-place=Washington, DC | date=2018 | isbn=978-0-8412-3391-1 | doi=10.1021/bk-2018-1311.ch001 | url=https://pubs.acs.org/doi/abs/10.1021/bk-2018-1311.ch001 | access-date=2026-04-21 | page=1–32}}] |