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In a 2023 study, ''C. elegans'' were [{{Cite journal |last=Quintin |first=Sophie |last2=Aspert |first2=Théo |last3=Ye |first3=Tao |last4=Charvin |first4=Gilles |date=2022-09-29 |title=Distinct mechanisms underlie H2O2 sensing in C. elegans head and tail |url=https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0274226 |journal=PLOS ONE |language=en |volume=17 |issue=9 |pages=e0274226 |doi=10.1371/journal.pone.0274226 |issn=1932-6203 |pmc=9521893 |pmid=36173997}}]
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Additionally, LITE-1 is more stable in the presence of [[Bardet–Biedl syndrome|Bardet-Biedl syndrome (BBS)]] which is rare genetic mutation, mediated by DLK-MAPK signaling, affecting the ASH photosensory neurons located at their head serving as ''C. elegans'' primarily defense against environmental hazards. [{{Cite journal |last=Quintin |first=Sophie |last2=Aspert |first2=Théo |last3=Ye |first3=Tao |last4=Charvin |first4=Gilles |date=2022-09-29 |title=Distinct mechanisms underlie H2O2 sensing in C. elegans head and tail |url=https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0274226 |journal=PLOS ONE |language=en |volume=17 |issue=9 |pages=e0274226 |doi=10.1371/journal.pone.0274226 |issn=1932-6203 |pmc=9521893 |pmid=36173997}}] |
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In a 2023 study, responses to X-Ray stimulation was tested on ''C. elegans'' of different variants including a wild type, lacking in LITE-1, and lacking in GUR-3. The wild type worms displayed locomotory avoidance behavior while the ones lacking in LITE-1 failed to respond whereas worms lacking in GUR-3 had normal reactions. This indicates that LITE-1, but not GUR-3, mediates X-ray-induced avoidance.[{{Cite journal |last=Cannon |first=Kelli E. |last2=Ranasinghe |first2=Meenakshi |last3=Millhouse |first3=Paul W. |last4=Roychowdhury |first4=Ayona |last5=Dobrunz |first5=Lynn E. |last6=Foulger |first6=Stephen H. |last7=Gauntt |first7=David M. |last8=Anker |first8=Jeffrey N. |last9=Bolding |first9=Mark |date=2023-08-10 |title=LITE-1 mediates behavioral responses to X-rays in Caenorhabditis elegans |url=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1210138/full |journal=Frontiers in Neuroscience |language=English |volume=17 |doi=10.3389/fnins.2023.1210138 |issn=1662-453X}}] |
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In a 2023 study, responses to X-Ray stimulation was tested on ''C. elegans'' of different variants including a wild type, lacking in LITE-1, and lacking in GUR-3. The wild type worms displayed locomotory avoidance behavior while the ones lacking in LITE-1 failed to respond whereas worms lacking in GUR-3 had normal reactions. This indicates that LITE-1, but not GUR-3, mediates X-ray-induced avoidance.[{{Cite journal |last=Cannon |first=Kelli E. |last2=Ranasinghe |first2=Meenakshi |last3=Millhouse |first3=Paul W. |last4=Roychowdhury |first4=Ayona |last5=Dobrunz |first5=Lynn E. |last6=Foulger |first6=Stephen H. |last7=Gauntt |first7=David M. |last8=Anker |first8=Jeffrey N. |last9=Bolding |first9=Mark |date=2023-08-10 |title=LITE-1 mediates behavioral responses to X-rays in Caenorhabditis elegans |url=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1210138/full |journal=Frontiers in Neuroscience |language=English |volume=17 |doi=10.3389/fnins.2023.1210138 |issn=1662-453X}}] |
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