Template:Relative affinities of estrogens for steroid hormone receptors and blood proteins

Template:Relative affinities of estrogens for steroid hormone receptors and blood proteins

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← Previous revision Revision as of 17:54, 25 April 2026
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! rowspan="2" | {{No selflink|Estrogen (medication)|Estrogen}} !! colspan="7" | [[Relative binding affinity|Relative binding affinities]] (%)
! rowspan="2" | {{No selflink|Estrogen (medication)|Estrogen}} !! colspan="7" | [[Relative binding affinity|Relative binding affinities]] (%)
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! {{abbrlink|ER|Estrogen receptor}} !! {{abbrlink|AR|Androgen receptor}} !! {{abbrlink|PR|Progesterone receptor}} !! {{abbrlink|GR|Glucocorticoid receptor}} !! {{abbrlink|MR|Mineralocorticoid receptor}} !! {{abbrlink|SHBG|Sex hormone-binding globulin}} !! {{abbrlink|CBG|Corticosteroid binding globulin}}
! {{abbrlink|ER|Estrogen receptor}} !! {{abbrlink|AR|Androgen receptor}} !! {{abbrlink|PR|Progesterone receptor}} !! {{abbrlink|GR|Glucocorticoid receptor}} !! {{abbrlink|MR|Mineralocorticoid receptor}} !! {{abbrlink|SHBG|Sex hormone-binding globulin}} !! {{abbrlink|CBG|Transcortin}}
|-
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| {{No selflink|Estradiol (medication)|Estradiol}} || 100 || 7.9 || 2.6 || 0.6 || 0.13 || 8.7–12 || <0.1
| {{No selflink|Estradiol (medication)|Estradiol}} || 100 || 7.9 || 2.6 || 0.6 || 0.13 || 8.7–12 || <0.1
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| {{No selflink|Diethylstilbestrol}} || ? || ? || ? || ? || ? || <0.1 || <0.1
| {{No selflink|Diethylstilbestrol}} || ? || ? || ? || ? || ? || <0.1 || <0.1
|- class="sortbottom"
|- class="sortbottom"
| colspan="8" style="width: 1px; background-color:var(--background-color-neutral,#eaecf0); color:inherit; text-align: center;" | '''Notes:''' Reference [[ligand (biochemistry)|ligand]]s (100%) were {{No selflink|progesterone (medication)|progesterone}} for the {{Abbrlink|PR|progesterone receptor}}, {{No selflink|testosterone (medication)|testosterone}} for the {{abbrlink|AR|androgen receptor}}, {{No selflink|estradiol (medication)|estradiol}} for the {{Abbrlink|ER|estrogen receptor}}, {{No selflink|dexamethasone}} for the {{Abbrlink|GR|glucocorticoid receptor}}, {{No selflink|aldosterone}} for the {{Abbrlink|MR|mineralocorticoid receptor}}, {{No selflink|androstanolone|dihydrotestosterone}} for {{Abbrlink|SHBG|sex hormone-binding globulin}}, and {{No selflink|hydrocortisone|cortisol}} for {{Abbrlink|CBG|Corticosteroid-binding globulin}}. '''Sources:''' {{cite book|last1=Raynaud|first1=J.P.|last2=Ojasoo|first2=T.|last3=Bouton|first3=M.M.|last4=Philibert|first4=D.|title=Drug Design|chapter=Receptor Binding as a Tool in the Development of New Bioactive Steroids|year=1979|pages=169–214|doi=10.1016/B978-0-12-060308-4.50010-X|isbn=9780120603084|chapter-url=https://books.google.com/books?id=bhAlBQAAQBAJ&pg=PA169}}{{cite journal | vauthors = Ojasoo T, Raynaud JP | title = Unique steroid congeners for receptor studies | journal = Cancer Res. | volume = 38 | issue = 11 Pt 2 | pages = 4186–98 | date = November 1978 | pmid = 359134 | url = http://cancerres.aacrjournals.org/content/38/11_Part_2/4186.short}}{{cite journal | vauthors = Ojasoo T, Delettré J, Mornon JP, Turpin-VanDycke C, Raynaud JP | title = Towards the mapping of the progesterone and androgen receptors | journal = J. Steroid Biochem. | volume = 27 | issue = 1–3 | pages = 255–69 | date = 1987 | pmid = 3695484 | doi = 10.1016/0022-4731(87)90317-7 }}{{cite journal | vauthors = Raynaud JP, Bouton MM, Moguilewsky M, Ojasoo T, Philibert D, Beck G, Labrie F, Mornon JP | title = Steroid hormone receptors and pharmacology | journal = J. Steroid Biochem. | volume = 12 | pages = 143–57 | date = January 1980 | pmid = 7421203 | doi = 10.1016/0022-4731(80)90264-2 }}{{cite journal | vauthors = Dunn JF, Nisula BC, Rodbard D | title = Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma | journal = J. Clin. Endocrinol. Metab. | volume = 53 | issue = 1 | pages = 58–68 | date = July 1981 | pmid = 7195404 | doi = 10.1210/jcem-53-1-58 }}{{cite journal | vauthors = Pugeat MM, Dunn JF, Nisula BC | title = Transport of steroid hormones: interaction of 70 drugs with testosterone-binding globulin and corticosteroid-binding globulin in human plasma | journal = J. Clin. Endocrinol. Metab. | volume = 53 | issue = 1 | pages = 69–75 | date = July 1981 | pmid = 7195405 | doi = 10.1210/jcem-53-1-69 }}{{cite journal | vauthors = Kuhl H | title = Pharmacology of estrogens and progestogens: influence of different routes of administration | journal = Climacteric | volume = 8 Suppl 1 | pages = 3–63 | year = 2005 | pmid = 16112947 | doi = 10.1080/13697130500148875 | s2cid = 24616324 | url = http://hormonebalance.org/images/documents/Kuhl%2005%20%20Pharm%20Estro%20Progest%20Climacteric_1313155660.pdf}}{{cite journal | vauthors = Kuhl H | title = Pharmacokinetics of oestrogens and progestogens | journal = Maturitas | volume = 12 | issue = 3 | pages = 171–97 | date = September 1990 | pmid = 2170822 | doi = 10.1016/0378-5122(90)90003-O }}See template.
| colspan="8" style="width: 1px; background-color:var(--background-color-neutral,#eaecf0); color:inherit; text-align: center;" | '''Notes:''' Reference [[ligand (biochemistry)|ligand]]s (100%) were {{No selflink|progesterone (medication)|progesterone}} for the {{Abbrlink|PR|progesterone receptor}}, {{No selflink|testosterone (medication)|testosterone}} for the {{abbrlink|AR|androgen receptor}}, {{No selflink|estradiol (medication)|estradiol}} for the {{Abbrlink|ER|estrogen receptor}}, {{No selflink|dexamethasone}} for the {{Abbrlink|GR|glucocorticoid receptor}}, {{No selflink|aldosterone}} for the {{Abbrlink|MR|mineralocorticoid receptor}}, {{No selflink|androstanolone|dihydrotestosterone}} for {{Abbrlink|SHBG|sex hormone-binding globulin}}, and {{No selflink|hydrocortisone|cortisol}} for {{Abbrlink|CBG|Transcortin}}. '''Sources:''' {{cite book|last1=Raynaud|first1=J.P.|last2=Ojasoo|first2=T.|last3=Bouton|first3=M.M.|last4=Philibert|first4=D.|title=Drug Design|chapter=Receptor Binding as a Tool in the Development of New Bioactive Steroids|year=1979|pages=169–214|doi=10.1016/B978-0-12-060308-4.50010-X|isbn=9780120603084|chapter-url=https://books.google.com/books?id=bhAlBQAAQBAJ&pg=PA169}}{{cite journal | vauthors = Ojasoo T, Raynaud JP | title = Unique steroid congeners for receptor studies | journal = Cancer Res. | volume = 38 | issue = 11 Pt 2 | pages = 4186–98 | date = November 1978 | pmid = 359134 | url = http://cancerres.aacrjournals.org/content/38/11_Part_2/4186.short}}{{cite journal | vauthors = Ojasoo T, Delettré J, Mornon JP, Turpin-VanDycke C, Raynaud JP | title = Towards the mapping of the progesterone and androgen receptors | journal = J. Steroid Biochem. | volume = 27 | issue = 1–3 | pages = 255–69 | date = 1987 | pmid = 3695484 | doi = 10.1016/0022-4731(87)90317-7 }}{{cite journal | vauthors = Raynaud JP, Bouton MM, Moguilewsky M, Ojasoo T, Philibert D, Beck G, Labrie F, Mornon JP | title = Steroid hormone receptors and pharmacology | journal = J. Steroid Biochem. | volume = 12 | pages = 143–57 | date = January 1980 | pmid = 7421203 | doi = 10.1016/0022-4731(80)90264-2 }}{{cite journal | vauthors = Dunn JF, Nisula BC, Rodbard D | title = Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma | journal = J. Clin. Endocrinol. Metab. | volume = 53 | issue = 1 | pages = 58–68 | date = July 1981 | pmid = 7195404 | doi = 10.1210/jcem-53-1-58 }}{{cite journal | vauthors = Pugeat MM, Dunn JF, Nisula BC | title = Transport of steroid hormones: interaction of 70 drugs with testosterone-binding globulin and corticosteroid-binding globulin in human plasma | journal = J. Clin. Endocrinol. Metab. | volume = 53 | issue = 1 | pages = 69–75 | date = July 1981 | pmid = 7195405 | doi = 10.1210/jcem-53-1-69 }}{{cite journal | vauthors = Kuhl H | title = Pharmacology of estrogens and progestogens: influence of different routes of administration | journal = Climacteric | volume = 8 Suppl 1 | pages = 3–63 | year = 2005 | pmid = 16112947 | doi = 10.1080/13697130500148875 | s2cid = 24616324 | url = http://hormonebalance.org/images/documents/Kuhl%2005%20%20Pharm%20Estro%20Progest%20Climacteric_1313155660.pdf}}{{cite journal | vauthors = Kuhl H | title = Pharmacokinetics of oestrogens and progestogens | journal = Maturitas | volume = 12 | issue = 3 | pages = 171–97 | date = September 1990 | pmid = 2170822 | doi = 10.1016/0378-5122(90)90003-O }}See template.
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