Sensodyne

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Sensodyne

← Previous revision Revision as of 16:49, 24 April 2026
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'''Sensodyne''' is a brand name of [[toothpaste]] and [[mouthwash]] targeted at people with [[dentine hypersensitivity|sensitive teeth]].{{cite news |title=SmithKline to swallow Sensodyne |first=Andrew |last=Clark |url=https://www.theguardian.com/business/2000/oct/07/13 |newspaper=The Guardian |date=October 7, 2000 |access-date=July 20, 2013 |archive-date=October 25, 2019 |archive-url=https://web.archive.org/web/20191025190014/https://www.theguardian.com/business/2000/oct/07/13 |url-status=live }} Sensodyne is owned by [[Haleon]] and is marketed under the name Shumitect in [[Japan]].{{cite web |url=http://www.gsk.com/products/our-consumer-healthcare-products/sensodyne.html |title=Sensodyne | Our consumer healthcare products | Products | GlaxoSmithKline |access-date=2013-03-17 |url-status=dead |archive-url=https://web.archive.org/web/20130305172855/http://www.gsk.com/products/our-consumer-healthcare-products/sensodyne.html |archive-date=2013-03-05 }}
'''Sensodyne''' is a brand name of [[toothpaste]] and [[mouthwash]] targeted at people with [[Dentin hypersensitivity|sensitive teeth]].{{cite news |title=SmithKline to swallow Sensodyne |first=Andrew |last=Clark |url=https://www.theguardian.com/business/2000/oct/07/13 |newspaper=The Guardian |date=October 7, 2000 |access-date=July 20, 2013 |archive-date=October 25, 2019 |archive-url=https://web.archive.org/web/20191025190014/https://www.theguardian.com/business/2000/oct/07/13 |url-status=live }} Sensodyne is owned by [[Haleon]] and is marketed under the name Shumitect in [[Japan]].{{cite web |url=http://www.gsk.com/products/our-consumer-healthcare-products/sensodyne.html |title=Sensodyne | Our consumer healthcare products | Products | GlaxoSmithKline |access-date=2013-03-17 |url-status=dead |archive-url=https://web.archive.org/web/20130305172855/http://www.gsk.com/products/our-consumer-healthcare-products/sensodyne.html |archive-date=2013-03-05 }}


==Effectiveness and ingredients==
==Effectiveness and ingredients==
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=== Potassium nitrate ===
=== Potassium nitrate ===
The [[potassium ion]] [[Hyperpolarization (biology)|hyperpolarizes]]{{cite book|last1=Walsh|first1=Margaret|title=Dental Hygiene: Theory and Practice|date=Apr 15, 2014|publisher=Elsevier Health Sciences|page=699|url=https://books.google.com/books?id=K_ULBAAAQBAJ&q=potassium+nitrate+hyperpolarization&pg=PA699|isbn=9781455745845|access-date=November 5, 2020|archive-date=February 27, 2024|archive-url=https://web.archive.org/web/20240227175712/https://books.google.com/books?id=K_ULBAAAQBAJ&q=potassium+nitrate+hyperpolarization&pg=PA699#v=snippet&q=potassium%20nitrate%20hyperpolarization&f=false|url-status=live}} the nerve and stops it from firing. The nerve impulses are thus desensitized and there is no pain.
The [[Potassium|potassium ion]] [[Hyperpolarization (biology)|hyperpolarizes]]{{cite book|last1=Walsh|first1=Margaret|title=Dental Hygiene: Theory and Practice|date=Apr 15, 2014|publisher=Elsevier Health Sciences|page=699|url=https://books.google.com/books?id=K_ULBAAAQBAJ&q=potassium+nitrate+hyperpolarization&pg=PA699|isbn=9781455745845|access-date=November 5, 2020|archive-date=February 27, 2024|archive-url=https://web.archive.org/web/20240227175712/https://books.google.com/books?id=K_ULBAAAQBAJ&q=potassium+nitrate+hyperpolarization&pg=PA699#v=snippet&q=potassium%20nitrate%20hyperpolarization&f=false|url-status=live}} the nerve and stops it from firing. The nerve impulses are thus desensitized and there is no pain.


=== Strontium acetate and strontium chloride ===
=== Strontium acetate and strontium chloride ===
These compounds share a similar chemical structure to [[calcium]]. Strontium based toothpastes (acetate and chloride) are therefore able to replace some of the lost calcium and block the exposed [[Dentinal tubule|tubules]] in the [[Dentin|dentinal tissue]]. This helps prevent the movement of the fluid within the tubules in response to a sensitivity stimulus that could otherwise cause tooth pain.{{cite journal|last1=Hughes|first1=N|last2=Layer|first2=T|title=Evidence for the efficacy of an 8% strontium acetate dentifrice for instant and lasting relief of dentin hypersensitivity.|journal=Journal of Clinical Dentistry|date=2010|volume=21|issue=5|pages=56–58|pmid=20669817}}
These compounds share a similar chemical structure to [[calcium]]. Strontium based toothpastes (acetate and chloride) are therefore able to replace some of the lost calcium and block the exposed [[Bone canaliculus|tubules]] in the [[Dentin|dentinal tissue]]. This helps prevent the movement of the fluid within the tubules in response to a sensitivity stimulus that could otherwise cause tooth pain.{{cite journal|last1=Hughes|first1=N|last2=Layer|first2=T|title=Evidence for the efficacy of an 8% strontium acetate dentifrice for instant and lasting relief of dentin hypersensitivity.|journal=Journal of Clinical Dentistry|date=2010|volume=21|issue=5|pages=56–58|pmid=20669817}}


=== Calcium sodium phosphosilicate ===
=== Calcium sodium phosphosilicate ===
Some Sensodyne products contain [[calcium sodium phosphosilicate]] (CSPS, Novamin), which appears to help with tooth sensitivity.{{Cite journal|last1=Freda|first1=Nicolas M|last2=Veitz-Keenan|first2=Analia|date=March 2016|title=Calcium sodium phosphosilicate had some benefit on dentine hypersensitivity: Question: Is calcium sodium phosphosilicate (CSPS) effective in reducing dentine hypersensitivity (DH) pain response?|journal=Evidence-Based Dentistry|volume=17|issue=1|pages=12–13|doi=10.1038/sj.ebd.6401148|pmid=27012568|s2cid=24049298}}{{cite web|last1=Goldie|first1=Maria|title=Potassium nitrate, sodium fluoride, strontium chloride, and NovaMin technologies for dentin hypersensitivity|url=http://www.dentistryiq.com/articles/2011/03/novamin-and-hypersensitivity.html|website=Dentistry IQ|date=15 March 2011|access-date=21 November 2014|archive-date=25 October 2019|archive-url=https://web.archive.org/web/20191025191342/https://www.dentistryiq.com/articles/2011/03/novamin-and-hypersensitivity.html|url-status=live}} A randomized clinical trial published in 2015 demonstrated that dentifrices containing 5% CSPS may have the potential to mineralize and occlude the dentine in the oral environment.{{Cite journal|last1=Jones|first1=Siân Bodfel|last2=Parkinson|first2=Charles R.|last3=Jeffery|first3=Peter|last4=Davies|first4=Maria|last5=Macdonald|first5=Emma L.|last6=Seong|first6=Joon|last7=West|first7=Nicola X.|date=June 2015|title=A randomised clinical trial investigating calcium sodium phosphosilicate as a dentine mineralising agent in the oral environment|journal=Journal of Dentistry|volume=43|issue=6|pages=757–764|doi=10.1016/j.jdent.2014.10.005|pmid=25456613}}{{Cite journal|last1=Hall|first1=Claire|last2=Mason|first2=Stephen|last3=Cooke|first3=Jonathan|date=May 2017|title=Exploratory randomised controlled clinical study to evaluate the comparative efficacy of two occluding toothpastes – a 5% calcium sodium phosphosilicate toothpaste and an 8% arginine/calcium carbonate toothpaste – for the longer-term relief of dentine hypersensitivity|journal=Journal of Dentistry|volume=60|pages=36–43|doi=10.1016/j.jdent.2017.02.009|pmid=28219674|doi-access=free}} Sensodyne products sold in the United States do not contain calcium sodium phosphosilicate (Novamin).
Some Sensodyne products contain [[Bioglass 45S5|calcium sodium phosphosilicate]] (CSPS, Novamin), which appears to help with tooth sensitivity.{{Cite journal|last1=Freda|first1=Nicolas M|last2=Veitz-Keenan|first2=Analia|date=March 2016|title=Calcium sodium phosphosilicate had some benefit on dentine hypersensitivity: Question: Is calcium sodium phosphosilicate (CSPS) effective in reducing dentine hypersensitivity (DH) pain response?|journal=Evidence-Based Dentistry|volume=17|issue=1|pages=12–13|doi=10.1038/sj.ebd.6401148|pmid=27012568|s2cid=24049298}}{{cite web|last1=Goldie|first1=Maria|title=Potassium nitrate, sodium fluoride, strontium chloride, and NovaMin technologies for dentin hypersensitivity|url=http://www.dentistryiq.com/articles/2011/03/novamin-and-hypersensitivity.html|website=Dentistry IQ|date=15 March 2011|access-date=21 November 2014|archive-date=25 October 2019|archive-url=https://web.archive.org/web/20191025191342/https://www.dentistryiq.com/articles/2011/03/novamin-and-hypersensitivity.html|url-status=live}} A randomized clinical trial published in 2015 demonstrated that dentifrices containing 5% CSPS may have the potential to mineralize and occlude the dentine in the oral environment.{{Cite journal|last1=Jones|first1=Siân Bodfel|last2=Parkinson|first2=Charles R.|last3=Jeffery|first3=Peter|last4=Davies|first4=Maria|last5=Macdonald|first5=Emma L.|last6=Seong|first6=Joon|last7=West|first7=Nicola X.|date=June 2015|title=A randomised clinical trial investigating calcium sodium phosphosilicate as a dentine mineralising agent in the oral environment|journal=Journal of Dentistry|volume=43|issue=6|pages=757–764|doi=10.1016/j.jdent.2014.10.005|pmid=25456613}}{{Cite journal|last1=Hall|first1=Claire|last2=Mason|first2=Stephen|last3=Cooke|first3=Jonathan|date=May 2017|title=Exploratory randomised controlled clinical study to evaluate the comparative efficacy of two occluding toothpastes – a 5% calcium sodium phosphosilicate toothpaste and an 8% arginine/calcium carbonate toothpaste – for the longer-term relief of dentine hypersensitivity|journal=Journal of Dentistry|volume=60|pages=36–43|doi=10.1016/j.jdent.2017.02.009|pmid=28219674|doi-access=free}} Sensodyne products sold in the United States do not contain calcium sodium phosphosilicate (Novamin).


==History==
==History==
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By 1925, manufacturing dental care products had become the company's focus. Leonard N. Block followed his father into the family business which relocated to [[Jersey City, New Jersey|Jersey City]], [[New Jersey]], in 1938.{{Cite news|url=https://www.nytimes.com/2005/11/12/business/leonard-block-93-chief-of-drug-company-is-dead.html|title=Leonard Block, 93, Chief of Drug Company, Is Dead|last=Saxon|first=Wolfgang|date=2005-11-12|work=The New York Times|access-date=2019-09-30|issn=0362-4331|archive-date=2019-09-30|archive-url=https://web.archive.org/web/20190930173618/https://www.nytimes.com/2005/11/12/business/leonard-block-93-chief-of-drug-company-is-dead.html|url-status=live}}
By 1925, manufacturing dental care products had become the company's focus. Leonard N. Block followed his father into the family business which relocated to [[Jersey City, New Jersey|Jersey City]], [[New Jersey]], in 1938.{{Cite news|url=https://www.nytimes.com/2005/11/12/business/leonard-block-93-chief-of-drug-company-is-dead.html|title=Leonard Block, 93, Chief of Drug Company, Is Dead|last=Saxon|first=Wolfgang|date=2005-11-12|work=The New York Times|access-date=2019-09-30|issn=0362-4331|archive-date=2019-09-30|archive-url=https://web.archive.org/web/20190930173618/https://www.nytimes.com/2005/11/12/business/leonard-block-93-chief-of-drug-company-is-dead.html|url-status=live}}


In 2000, Block Drug was purchased by Smith Kline Beecham P.L.C.,{{Cite news|url=https://www.nytimes.com/2000/10/10/business/company-news-smithkline-to-buy-block-drug-for-1.2-billion.html|title=Company News; Smithkline to Buy Block Drug for $1.2 Billion|date=2000-10-10|work=The New York Times|access-date=2019-09-30|issn=0362-4331|archive-date=2019-04-02|archive-url=https://web.archive.org/web/20190402030620/https://www.nytimes.com/2000/10/10/business/company-news-smithkline-to-buy-block-drug-for-1.2-billion.html|url-status=live}} which became [[GlaxoSmithKline]] (NYSE:GSK).{{Cite web|url=https://www.latimes.com/archives/la-xpm-2000-dec-28-fi-5687-story.html|title=Firms Complete Merger of GlaxoSmithKline|date=2000-12-28|website=Los Angeles Times|access-date=2019-09-30|archive-date=2019-09-30|archive-url=https://web.archive.org/web/20190930173619/https://www.latimes.com/archives/la-xpm-2000-dec-28-fi-5687-story.html|url-status=live}}
In 2000, Block Drug was purchased by Smith Kline Beecham P.L.C.,{{Cite news|url=https://www.nytimes.com/2000/10/10/business/company-news-smithkline-to-buy-block-drug-for-1.2-billion.html|title=Company News; Smithkline to Buy Block Drug for $1.2 Billion|date=2000-10-10|work=The New York Times|access-date=2019-09-30|issn=0362-4331|archive-date=2019-04-02|archive-url=https://web.archive.org/web/20190402030620/https://www.nytimes.com/2000/10/10/business/company-news-smithkline-to-buy-block-drug-for-1.2-billion.html|url-status=live}} which became [[GSK plc|GSK]] (NYSE:GSK).{{Cite web|url=https://www.latimes.com/archives/la-xpm-2000-dec-28-fi-5687-story.html|title=Firms Complete Merger of GlaxoSmithKline|date=2000-12-28|website=Los Angeles Times|access-date=2019-09-30|archive-date=2019-09-30|archive-url=https://web.archive.org/web/20190930173619/https://www.latimes.com/archives/la-xpm-2000-dec-28-fi-5687-story.html|url-status=live}}


The toothpaste was first marketed in 1961 as a desensitising [[toothpaste]] based on a [[strontium chloride]] formulation.{{Citation needed|date=November 2019}} In 1980,{{Citation needed|date=July 2013}} Sensodyne launched a new toothpaste containing [[potassium nitrate]], a mild local [[sedative]].{{cite news |title=All About/Toothpaste; Growth Is Glacial, but the Market Is Big, and So Is the Gross |first=Anthony |last=Ramirez |url=https://www.nytimes.com/1990/05/13/business/all-about-toothpaste-growth-is-glacial-but-the-market-is-big-and-so-is-the-gross.html |newspaper=The New York Times |date=May 13, 1990 |access-date=July 20, 2013 |archive-date=August 26, 2014 |archive-url=https://web.archive.org/web/20140826133754/http://www.nytimes.com/1990/05/13/business/all-about-toothpaste-growth-is-glacial-but-the-market-is-big-and-so-is-the-gross.html |url-status=live }}
The toothpaste was first marketed in 1961 as a desensitising [[toothpaste]] based on a [[strontium chloride]] formulation.{{Citation needed|date=November 2019}} In 1980,{{Citation needed|date=July 2013}} Sensodyne launched a new toothpaste containing [[potassium nitrate]], a mild local [[sedative]].{{cite news |title=All About/Toothpaste; Growth Is Glacial, but the Market Is Big, and So Is the Gross |first=Anthony |last=Ramirez |url=https://www.nytimes.com/1990/05/13/business/all-about-toothpaste-growth-is-glacial-but-the-market-is-big-and-so-is-the-gross.html |newspaper=The New York Times |date=May 13, 1990 |access-date=July 20, 2013 |archive-date=August 26, 2014 |archive-url=https://web.archive.org/web/20140826133754/http://www.nytimes.com/1990/05/13/business/all-about-toothpaste-growth-is-glacial-but-the-market-is-big-and-so-is-the-gross.html |url-status=live }}
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== Product counterfeits and recall ==
== Product counterfeits and recall ==


In 2007, [[GlaxoSmithKline]] tracked down counterfeit producers of Sensodyne after a consumer in Panama noted [[diethylene glycol]], a poisonous ingredient commonly found in antifreeze, on the label of his toothpaste.Colgate and Sensodyne, got caught up in the sweep when counterfeiters were found to be selling toothpaste with antifreeze under their names. {{cite news |last1=BOGDANICH |first1=WALT |title=The Everyman Who Exposed Tainted Toothpaste |url=https://www.nytimes.com/2007/10/01/world/americas/01panama.html |access-date=2 April 2019 |work=The New York Times |date=October 1, 2007 |archive-date=16 January 2018 |archive-url=https://web.archive.org/web/20180116182004/http://www.nytimes.com/2007/10/01/world/americas/01panama.html |url-status=live }}
In 2007, [[GSK plc|GSK]] tracked down counterfeit producers of Sensodyne after a consumer in Panama noted [[diethylene glycol]], a poisonous ingredient commonly found in antifreeze, on the label of his toothpaste.Colgate and Sensodyne, got caught up in the sweep when counterfeiters were found to be selling toothpaste with antifreeze under their names. {{cite news |last1=BOGDANICH |first1=WALT |title=The Everyman Who Exposed Tainted Toothpaste |url=https://www.nytimes.com/2007/10/01/world/americas/01panama.html |access-date=2 April 2019 |work=The New York Times |date=October 1, 2007 |archive-date=16 January 2018 |archive-url=https://web.archive.org/web/20180116182004/http://www.nytimes.com/2007/10/01/world/americas/01panama.html |url-status=live }}


On July 15, 2015, [[GlaxoSmithKline]] Consumer Healthcare announced a recall of certain lots of Sensodyne Repair & Protect toothpaste as well as Sensodyne Complete toothpaste due to the possible presence of wood fragments in the products. The recall also applied to the company's Biotene brand of toothpaste. The recall was a precautionary measure based on a small number of complaints, and no injuries have been reported. The recall applies to products manufactured between 2013 and September 2014, and shipped from June 2013 to April 2015.{{Cite web|url=http://www.smithdrug.com/uploads/recalls/sensodyne-biotine.pdf|title=Urgent: Product Recall – Retail Level|date=15 July 2015|website=Smith Drug|access-date=21 August 2015|archive-date=7 August 2015|archive-url=https://web.archive.org/web/20150807173157/http://www.smithdrug.com/uploads/recalls/sensodyne-biotine.pdf|url-status=live}}
On July 15, 2015, [[GSK plc|GSK]] Consumer Healthcare announced a recall of certain lots of Sensodyne Repair & Protect toothpaste as well as Sensodyne Complete toothpaste due to the possible presence of wood fragments in the products. The recall also applied to the company's Biotene brand of toothpaste. The recall was a precautionary measure based on a small number of complaints, and no injuries have been reported. The recall applies to products manufactured between 2013 and September 2014, and shipped from June 2013 to April 2015.{{Cite web|url=http://www.smithdrug.com/uploads/recalls/sensodyne-biotine.pdf|title=Urgent: Product Recall – Retail Level|date=15 July 2015|website=Smith Drug|access-date=21 August 2015|archive-date=7 August 2015|archive-url=https://web.archive.org/web/20150807173157/http://www.smithdrug.com/uploads/recalls/sensodyne-biotine.pdf|url-status=live}}


==See also==
==See also==
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