Picloram

In regards to occupational exposures, the U. S. [[Occupational Safety and Health Administration]] has established a [[permissible exposure limit]] of 15 mg/m³ total exposure and 5 mg/m³ for respiratory exposure, over an eight-hour workshift.[https://www.cdc.gov/niosh/npg/npgd0514.html NIOSH Pocket Guide to Chemical Hazards], Centers for Disease Control and Prevention

In regards to occupational exposures, the U. S. [[Occupational Safety and Health Administration]] has established a [[permissible exposure limit]] of 15 mg/m³ total exposure and 5 mg/m³ for respiratory exposure, over an eight-hour workshift.[https://www.cdc.gov/niosh/npg/npgd0514.html NIOSH Pocket Guide to Chemical Hazards], Centers for Disease Control and Prevention

===Carcinogenicity===

A 2026 study in ''Nature Medicine'' reported an association between picloram exposure signatures and early-onset [[colorectal cancer]]. The researchers used [[DNA methylation]] scores as indirect markers of previous exposure to lifestyle and environmental factors, including [[pesticides]]. A higher picloram-related methylation score was associated with colorectal cancer diagnosed before age 50, compared with colorectal cancer diagnosed at age 70 or older. This association was replicated in a meta-analysis of nine colorectal cancer cohorts.{{cite journal |last1=Maas |first1=Silvana C. E. |last2=Baraibar |first2=Iosune |last3=Lemler |first3=Lea |last4=Butjosa-Espín |first4=Maria |last5=Blanco Irazuegui |first5=Odei |last6=Tabernero |first6=Josep |last7=Elez |first7=Elena |last8=Seoane |first8=Jose A. |title=Epigenetic fingerprints link early-onset colon and rectal cancer to pesticide exposure |journal=Nature Medicine |year=2026 |doi=10.1038/s41591-026-04342-5}}

The same study also compared estimated pesticide use with cancer incidence in 94 United States counties over 21 years. Picloram use remained associated with early-onset colorectal cancer incidence after adjustment for socioeconomic factors and other pesticide use. The authors noted that picloram was first registered as a [[herbicide]] in the United States in 1964, so people who could have been exposed to it from childhood would often still be younger than 70 in 2026. They suggested that this could partly explain why the association was mainly seen for early-onset disease. The study found an association, but did not perform research to (dis)prove that picloram causes colorectal cancer. Therefore, the authors stated that further longitudinal and experimental research is needed to test [[causality]], dose dependence and latency.

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