Niranjan Parajuli

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Niranjan Parajuli

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== Research ==
== Research ==
Parajuli’s research focuses on microbial biotechnologyJe, W. P.; Hong, J. S. J.; Parajuli, N.; Won, S. J.; Sung, R. P.; Lim, S.-K.; Jae, K. S.; Yeo, J. Y. Genetic Dissection of the Biosynthetic Route to Gentamicin A2 by Heterologous Expression of Its Minimal Gene Set. Proceedings of the National Academy of Sciences of the United States of America 2008, 105 (24), 8399–8404., natural product discoveryBudhathoki, R.; Timilsina, A. P.; Regmi, B. P.; Sharma, K. R.; Aryal, N.; Parajuli, N. Metabolome Mining of Curcuma Longa L. Using HPLC-MS/MS and Molecular Networking. Metabolites 2023, 13 (8), 898. https://doi.org/10.3390/metabo13080898., protein engineeringParajuli, N.; Williams, G. J. A High-Throughput Screen for Directed Evolution of Aminocoumarin Amide Synthetases. Analytical Biochemistry 2011, 419 (1), 61–66. https://doi.org/10.1016/j.ab.2011.07.037., and computational chemistryUpadhyaya, S. R.; Bashyal, J.; Raut, B. K.; Parajuli, N. In Silico Study of Therapeutic Potential of Natural Polyphenol Derivatives Targeting Pancreatic Lipase. Discover Chemistry 2025, 2 (1). https://doi.org/10.1007/s44371-025-00266-0.Raut, B. K.; Upadhyaya, S. R.; Bashyal, J.; Parajuli, N. In Silico and In Vitro Analyses to Repurpose Quercetin as a Human Pancreatic α-Amylase Inhibitor. ACS Omega 2023, 8 (46), 43617–43631. https://doi.org/10.1021/acsomega.3c05082.Shrestha, A.; Upadhyaya, S. R.; Raut, B. K.; Bhattarai, S.; Sharma, K. R.; Parajuli, N.; Sohng, J. K.; Regmi, B. P. In Silico and In Vitro Analyses of Multiple Terpenes Predict Cryptotanshinone as a Potent Inhibitor of the Omicron Variant of SARS-CoV-2. Processes 2024, 12 (1), 230. https://doi.org/10.3390/pr12010230.. His work includes genome miningPoudel, P. B.; Dhakal, D.; Magar, R. T.; Parajuli, N.; Sohng, J. K. Genome Mining and Genetic Manipulation Reveal New Isofuranonaphthoquinones in Nocardia Species. International Journal of Molecular Sciences 2024, 25 (16), 8847. https://doi.org/10.3390/ijms25168847.Bridget, A. F.; Budhathoki, R.; Huo, C.; Joshi, S.; Parajuli, N.; Sohng, J. K.; Kim, K. H. Activation of Cryptic Biosynthetic Pathways in Saccharopolyspora Spinosa through Deletion of the Spinosyn Gene Cluster: Induction of Cryptic and Bioactive Natural Products. Archives of Pharmacal Research 2025, 48 (6), 514–527. https://doi.org/10.1007/s12272-025-01553-1., metabolomicsJoshi, S.; Huo, C.; Budhathoki, R.; Gurung, A.; Bhattarai, S.; Sharma, K. R.; Kim, K. H.; Parajuli, N. HPLC-ESI-HRMS/MS-Based Metabolite Profiling and Bioactivity Assessment of Catharanthus Roseus. Plants 2025, 14 (15), 2395. https://doi.org/10.3390/plants14152395. and in silico studies of bioactive compoundsUpadhyaya, S. R.; Bashyal, J.; Raut, B. K.; Parajuli, N. In Silico Study of Therapeutic Potential of Natural Polyphenol Derivatives Targeting Pancreatic Lipase. Discover Chemistry 2025, 2 (1). https://doi.org/10.1007/s44371-025-00266-0.Raut, B. K.; Upadhyaya, S. R.; Bashyal, J.; Parajuli, N. In Silico and In Vitro Analyses to Repurpose Quercetin as a Human Pancreatic α-Amylase Inhibitor. ACS Omega 2023, 8 (46), 43617–43631. https://doi.org/10.1021/acsomega.3c05082.Shrestha, A.; Upadhyaya, S. R.; Raut, B. K.; Bhattarai, S.; Sharma, K. R.; Parajuli, N.; Sohng, J. K.; Regmi, B. P. In Silico and In Vitro Analyses of Multiple Terpenes Predict Cryptotanshinone as a Potent Inhibitor of the Omicron Variant of SARS-CoV-2. Processes 2024, 12 (1), 230. https://doi.org/10.3390/pr12010230.. He has published studies on antibiotic biosynthesis, secondary metabolites from plants and microorganisms, and therapeutic compound modeling.
Parajuli’s research focuses on microbial biotechnologyJe, W. P.; Hong, J. S. J.; Parajuli, N.; Won, S. J.; Sung, R. P.; Lim, S.-K.; Jae, K. S.; Yeo, J. Y. Genetic Dissection of the Biosynthetic Route to Gentamicin A2 by Heterologous Expression of Its Minimal Gene Set. Proceedings of the National Academy of Sciences of the United States of America 2008, 105 (24), 8399–8404., natural product discoveryBudhathoki, R.; Timilsina, A. P.; Regmi, B. P.; Sharma, K. R.; Aryal, N.; Parajuli, N. Metabolome Mining of Curcuma Longa L. Using HPLC-MS/MS and Molecular Networking. Metabolites 2023, 13 (8), 898. https://doi.org/10.3390/metabo13080898., protein engineeringParajuli, N.; Williams, G. J. A High-Throughput Screen for Directed Evolution of Aminocoumarin Amide Synthetases. Analytical Biochemistry 2011, 419 (1), 61–66. https://doi.org/10.1016/j.ab.2011.07.037., and computational chemistryUpadhyaya, S. R.; Bashyal, J.; Raut, B. K.; Parajuli, N. In Silico Study of Therapeutic Potential of Natural Polyphenol Derivatives Targeting Pancreatic Lipase. Discover Chemistry 2025, 2 (1). https://doi.org/10.1007/s44371-025-00266-0.Raut, B. K.; Upadhyaya, S. R.; Bashyal, J.; Parajuli, N. In Silico and In Vitro Analyses to Repurpose Quercetin as a Human Pancreatic α-Amylase Inhibitor. ACS Omega 2023, 8 (46), 43617–43631. https://doi.org/10.1021/acsomega.3c05082.Shrestha, A.; Upadhyaya, S. R.; Raut, B. K.; Bhattarai, S.; Sharma, K. R.; Parajuli, N.; Sohng, J. K.; Regmi, B. P. In Silico and In Vitro Analyses of Multiple Terpenes Predict Cryptotanshinone as a Potent Inhibitor of the Omicron Variant of SARS-CoV-2. Processes 2024, 12 (1), 230. https://doi.org/10.3390/pr12010230.. His work includes genome miningPoudel, P. B.; Dhakal, D.; Magar, R. T.; Parajuli, N.; Sohng, J. K. Genome Mining and Genetic Manipulation Reveal New Isofuranonaphthoquinones in Nocardia Species. International Journal of Molecular Sciences 2024, 25 (16), 8847. https://doi.org/10.3390/ijms25168847.Bridget, A. F.; Budhathoki, R.; Huo, C.; Joshi, S.; Parajuli, N.; Sohng, J. K.; Kim, K. H. Activation of Cryptic Biosynthetic Pathways in Saccharopolyspora Spinosa through Deletion of the Spinosyn Gene Cluster: Induction of Cryptic and Bioactive Natural Products. Archives of Pharmacal Research 2025, 48 (6), 514–527. https://doi.org/10.1007/s12272-025-01553-1., [[metabolomics]]Joshi, S.; Huo, C.; Budhathoki, R.; Gurung, A.; Bhattarai, S.; Sharma, K. R.; Kim, K. H.; Parajuli, N. HPLC-ESI-HRMS/MS-Based Metabolite Profiling and Bioactivity Assessment of Catharanthus Roseus. Plants 2025, 14 (15), 2395. https://doi.org/10.3390/plants14152395. and in silico studies of bioactive compoundsUpadhyaya, S. R.; Bashyal, J.; Raut, B. K.; Parajuli, N. In Silico Study of Therapeutic Potential of Natural Polyphenol Derivatives Targeting Pancreatic Lipase. Discover Chemistry 2025, 2 (1). https://doi.org/10.1007/s44371-025-00266-0.Raut, B. K.; Upadhyaya, S. R.; Bashyal, J.; Parajuli, N. In Silico and In Vitro Analyses to Repurpose Quercetin as a Human Pancreatic α-Amylase Inhibitor. ACS Omega 2023, 8 (46), 43617–43631. https://doi.org/10.1021/acsomega.3c05082.Shrestha, A.; Upadhyaya, S. R.; Raut, B. K.; Bhattarai, S.; Sharma, K. R.; Parajuli, N.; Sohng, J. K.; Regmi, B. P. In Silico and In Vitro Analyses of Multiple Terpenes Predict Cryptotanshinone as a Potent Inhibitor of the Omicron Variant of SARS-CoV-2. Processes 2024, 12 (1), 230. https://doi.org/10.3390/pr12010230.. He has published studies on antibiotic biosynthesis, secondary metabolites from plants and microorganisms, and therapeutic compound modeling.
== Awards and recognition ==
== Awards and recognition ==
* Mahendra Vidya Bhushan A and B, Government of Nepal
* Mahendra Vidya Bhushan A and B, Government of Nepal
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Parajuli is married to journalist Madhabi Bhatta and has two sons.
Parajuli is married to journalist Madhabi Bhatta and has two sons.
== Selected publications ==
== Selected publications ==
# Park, J.W., Hong, J.S.J., Parajuli, N., et al. “Genetic dissection of the biosynthetic route to gentamicin A2 by heterologous expression of its minimal gene set.” Proceedings of the National Academy of Sciences, 105, 8399–8404 (2008).
# Park, J.W., Hong, J.S.J., Parajuli, N., et al. “Genetic dissection of the biosynthetic route to gentamicin A2 by heterologous expression of its minimal gene set.” Proceedings of the [[National Academy of Sciences]], 105, 8399–8404 (2008).
# Parajuli, N., Williams, G.J. “A high-throughput screen for directed evolution of aminocoumarin amide synthetases.” Analytical Biochemistry, 419, 61–66 (2011).
# Parajuli, N., Williams, G.J. “A high-throughput screen for directed evolution of aminocoumarin amide synthetases.” Analytical Biochemistry, 419, 61–66 (2011).
# Upadhyaya, S.R., Bashyal, J., Raut, B.K., Parajuli, N. “In silico study of therapeutic potential of natural polyphenol derivatives targeting pancreatic lipase.” Discover Chemistry, 2, 189 (2025).
# Upadhyaya, S.R., Bashyal, J., Raut, B.K., Parajuli, N. “In silico study of therapeutic potential of natural polyphenol derivatives targeting pancreatic lipase.” Discover Chemistry, 2, 189 (2025).
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