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In 2001 Cliche auditioned for a part in Vampire High. She was cast as the vampire Essie Rachimova.[{{cite web|url=http://www.vampirehigh.co.uk/karen-cliche-interview|title=Karen Cliche Interview|publisher=Vampire High|access-date=10 July 2017|archive-date=20 October 2017|archive-url=https://web.archive.org/web/20171020032639/http://www.vampirehigh.co.uk/karen-cliche-interview|url-status=dead}}] |
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In 2001, Cliche auditioned for a part in Vampire High. She was cast as the vampire Essie Rachimova.[{{cite web|url=http://www.vampirehigh.co.uk/karen-cliche-interview|title=Karen Cliche Interview|publisher=Vampire High|access-date=10 July 2017|archive-date=20 October 2017|archive-url=https://web.archive.org/web/20171020032639/http://www.vampirehigh.co.uk/karen-cliche-interview|url-status=dead}}] |
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In 2017, she played Jessica in ''Killer Mom''. Jessica is a mother who first meets her daughter Allison and wants to be the mother Allison never had.[{{cite web |url=http://heavy.com/entertainment/2017/04/killer-mom-cast-lifetime-new-movie-characters-photos-time-plot-actors-karen-cliche/|title='Killer Mom': Meet the Cast of Lifetime's New Movie |publisher=Heavy |access-date=10 July 2017}}] |
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In 2017, she played Jessica in ''Killer Mom''. Jessica is a mother who first meets her daughter Allison and wants to be the mother Allison never had.[{{cite web |url=http://heavy.com/entertainment/2017/04/killer-mom-cast-lifetime-new-movie-characters-photos-time-plot-actors-karen-cliche/|title='Killer Mom': Meet the Cast of Lifetime's New Movie |publisher=Heavy |access-date=10 July 2017}}] |