Gypenoside

Apr 22, 2026 - 21:20
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Gypenoside

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← Previous revision Revision as of 15:48, 22 April 2026
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Gypenosides can be divided into two main structual families, the [[dammarane]]-type and the [[cucurbitane]]-type. The dammarane-type saponins include compounds that are identical to those found in ginseng ([[ginsenoside]]s Rb1, Rb3, F2, Rg3, Rc, Rd, malonyl-Rb1, and malonyl-Rd) as well as those that are chemically similar.{{citation |title=Progress in the Medicinal Value, Bioactive Compounds, and Pharmacological Activities of Gynostemma pentaphyllum |date=2021 |pmc=8540791 |last1=Su |first1=C. |last2=Li |first2=N. |last3=Ren |first3=R. |last4=Wang |first4=Y. |last5=Su |first5=X. |last6=Lu |first6=F. |last7=Zong |first7=R. |last8=Yang |first8=L. |last9=Ma |first9=X. |journal=Molecules (Basel, Switzerland) |volume=26 |issue=20 |page=6249 |doi=10.3390/molecules26206249 |doi-access=free |pmid=34684830 }} As a result there is some interest in exploiting ''Gynostemma'' as a more scalable source of ginsenosides.{{cite journal |last1=Liang |first1=Tongtong |last2=Zou |first2=Liqiu |last3=Sun |first3=Sijie |last4=Kuang |first4=Xuejun |last5=Wei |first5=Jianhe |last6=Wang |first6=Lizhi |last7=Li |first7=Ying |last8=Sun |first8=Chao |title=Hybrid sequencing of the Gynostemma pentaphyllum transcriptome provides new insights into gypenoside biosynthesis |journal=BMC Genomics |date=December 2019 |volume=20 |issue=1 |doi=10.1186/s12864-019-6000-y}}
Gypenosides can be divided into two main structual families, the [[dammarane]]-type and the [[cucurbitane]]-type. The dammarane-type saponins include compounds that are identical to those found in ginseng ([[ginsenoside]]s Rb1, Rb3, F2, Rg3, Rc, Rd, malonyl-Rb1, and malonyl-Rd) as well as those that are chemically similar.{{citation |title=Progress in the Medicinal Value, Bioactive Compounds, and Pharmacological Activities of Gynostemma pentaphyllum |date=2021 |pmc=8540791 |last1=Su |first1=C. |last2=Li |first2=N. |last3=Ren |first3=R. |last4=Wang |first4=Y. |last5=Su |first5=X. |last6=Lu |first6=F. |last7=Zong |first7=R. |last8=Yang |first8=L. |last9=Ma |first9=X. |journal=Molecules (Basel, Switzerland) |volume=26 |issue=20 |page=6249 |doi=10.3390/molecules26206249 |doi-access=free |pmid=34684830 }} As a result there is some interest in exploiting ''Gynostemma'' as a more scalable source of ginsenosides.{{cite journal |last1=Liang |first1=Tongtong |last2=Zou |first2=Liqiu |last3=Sun |first3=Sijie |last4=Kuang |first4=Xuejun |last5=Wei |first5=Jianhe |last6=Wang |first6=Lizhi |last7=Li |first7=Ying |last8=Sun |first8=Chao |title=Hybrid sequencing of the Gynostemma pentaphyllum transcriptome provides new insights into gypenoside biosynthesis |journal=BMC Genomics |date=December 2019 |volume=20 |issue=1 |doi=10.1186/s12864-019-6000-y}}


Some gypenosides are sweet-tasting. They are responsible for the sweet taste of the plant.{{cite journal |last1=Zhang |first1=Hong-Xia |last2=Zhou |first2=Hui-Wei |last3=Liu |first3=Shou-Qing |last4=Zheng |first4=Zhi-Feng |last5=Du |first5=Zhi-Zhi |title=New Sweet-Tasting Gypenosides from “Jiaogulan” ( Gynostemma pentaphyllum ) and Their Interactions with the Homology Model of Sweet Taste Receptors |journal=Journal of Agricultural and Food Chemistry |date=21 August 2024 |volume=72 |issue=33 |pages=18619–18629 |doi=10.1021/acs.jafc.4c03566}}
Some gypenosides are sweet-tasting, with one being 200 times as sweet as sucrose. Some other gypenosides are bitter-tasting. Both contribute to the taste of the plant.{{cite journal |last1=Zhang |first1=Hong-Xia |last2=Zhou |first2=Hui-Wei |last3=Liu |first3=Shou-Qing |last4=Zheng |first4=Zhi-Feng |last5=Du |first5=Zhi-Zhi |title=New Sweet-Tasting Gypenosides from “Jiaogulan” ( Gynostemma pentaphyllum ) and Their Interactions with the Homology Model of Sweet Taste Receptors |journal=Journal of Agricultural and Food Chemistry |date=21 August 2024 |volume=72 |issue=33 |pages=18619–18629 |doi=10.1021/acs.jafc.4c03566}}


Gypenoside A has the chemical formula C46H74O17. It has a dammarane backbone attached to a chain of three sugars at the C-3 position.{{Cite web| last = Pubchem| title = Gypenoside A| access-date = 2026-04-22| url = https://pubchem.ncbi.nlm.nih.gov/compound/131849056}}
Gypenoside A has the chemical formula C46H74O17. It has a dammarane backbone attached to a chain of three sugars at the C-3 position.{{Cite web| last = Pubchem| title = Gypenoside A| access-date = 2026-04-22| url = https://pubchem.ncbi.nlm.nih.gov/compound/131849056}}
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