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In 1985, Greenberg reported that, instead of a complex mechanism, the autoinducer simply [[Diffusion|passively diffuses]] from one bacterial cell to another,[{{cite journal |last1=Kaplan |first1=Heidi B. |last2=Greenberg |first2=E. P. |title=Diffusion of Autoinducer Is Involved in Regulation of the Vibrio fischeri Luminescence System |journal=Journal of Bacteriology |date=1985 |volume=163 |issue=3 |pages=1210–1214 |doi=10.1128/jb.163.3.1210-1214.1985 |pmid=3897188 |pmc=219261 |doi-access=free}}] revealing one of the mechanisms of bacterial communication. |
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In 1985, Greenberg reported that, instead of a complex mechanism, the autoinducer simply [[Diffusion|passively diffuses]] from one bacterial cell to another,[{{cite journal |last1=Kaplan |first1=Heidi B. |last2=Greenberg |first2=E. P. |title=Diffusion of Autoinducer Is Involved in Regulation of the Vibrio fischeri Luminescence System |journal=Journal of Bacteriology |date=1985 |volume=163 |issue=3 |pages=1210–1214 |doi=10.1128/jb.163.3.1210-1214.1985 |pmid=3897188 |pmc=219261 |doi-access=free}}] revealing one of the mechanisms of bacterial communication. |
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He switched course after moving to the [[University of Iowa]], focusing on the luxR [[protein]] in ''A. fischeri''; the protein is a [[transcription factor]] activated by the autoinducer.[{{cite journal |last1=Whiteley |first1=Marvin |last2=Diggle |first2=Stephen P. |last3=Greenberg |first3=E. Peter |title=Progress in and promise of bacterial quorum sensing research |journal=Nature |date=2017 |volume=551 |issue=7680 |pages=313–320 |doi=10.1038/nature24624 |pmid=29144467 |pmc=5870893|bibcode=2017Natur.551..313W }}] Research by Greenberg's team confirmed the [[C-terminus]] of luxR binds [[DNA]][{{cite journal |last1=Choi |first1=S. H. |last2=Greenberg |first2=E. P. |title=The C-terminal region of the Vibrio fischeri LuxR protein contains an inducer-independent lux gene activating domain |journal=Proceedings of the National Academy of Sciences |date=1991 |volume=88 |issue=24 |pages=11115–11119 |doi=10.1073/pnas.88.24.11115 |pmid=1763027 |doi-access=free |pmc=53084 |bibcode=1991PNAS...8811115C }}] while its [[N-terminus]] binds the autoinducer.[{{cite journal |last1=Hanzelka |first1=Brian L. |last2=Greenberg |first2=E. P. |title=Evidence that the N-terminal region of the Vibrio fischeri LuxR protein constitutes an autoinducer-binding domain |journal=Journal of Bacteriology |date=1995 |volume=177 |issue=3 |pages=815–817 |doi=10.1128/jb.177.3.815-817.1995 |pmid=7836318 |doi-access=free |pmc=176662 }}] |
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He switched course after moving to the [[University of Iowa]], focusing on the luxR [[protein]] in ''A. fischeri''; the protein is a [[transcription factor]] activated by the autoinducer.[{{cite journal |author1-link=Marvin Whiteley |last1=Whiteley |first1=Marvin |last2=Diggle |first2=Stephen P. |last3=Greenberg |first3=E. Peter |title=Progress in and promise of bacterial quorum sensing research |journal=Nature |date=2017 |volume=551 |issue=7680 |pages=313–320 |doi=10.1038/nature24624 |pmid=29144467 |pmc=5870893|bibcode=2017Natur.551..313W }}] Research by Greenberg's team confirmed the [[C-terminus]] of luxR binds [[DNA]][{{cite journal |last1=Choi |first1=S. H. |last2=Greenberg |first2=E. P. |title=The C-terminal region of the Vibrio fischeri LuxR protein contains an inducer-independent lux gene activating domain |journal=Proceedings of the National Academy of Sciences |date=1991 |volume=88 |issue=24 |pages=11115–11119 |doi=10.1073/pnas.88.24.11115 |pmid=1763027 |doi-access=free |pmc=53084 |bibcode=1991PNAS...8811115C }}] while its [[N-terminus]] binds the autoinducer.[{{cite journal |last1=Hanzelka |first1=Brian L. |last2=Greenberg |first2=E. P. |title=Evidence that the N-terminal region of the Vibrio fischeri LuxR protein constitutes an autoinducer-binding domain |journal=Journal of Bacteriology |date=1995 |volume=177 |issue=3 |pages=815–817 |doi=10.1128/jb.177.3.815-817.1995 |pmid=7836318 |doi-access=free |pmc=176662 }}] |
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In a seminal article in 1994, Greenberg, together with Claiborne (Clay) Fuqua and Stephen Winans, at the time both from [[Cornell University]], coined the term [[quorum sensing]] to describe the behavior of autoinduced bioluminescence in ''A. fischeri'' and other bacterial [[species]].[{{cite journal |last1=Fuqua |first1=W. Claiborne |last2=Winans |first2=Stephen C. |last3=Greenberg |first3=E. Peter |title=Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators |journal=Journal of Bacteriology |date=1994 |volume=176 |issue=2 |pages=269–275 |doi=10.1128/jb.176.2.269-275.1994 |pmid=8288518 |pmc=205046 |doi-access=free }}] |
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In a seminal article in 1994, Greenberg, together with Claiborne (Clay) Fuqua and Stephen Winans, at the time both from [[Cornell University]], coined the term [[quorum sensing]] to describe the behavior of autoinduced bioluminescence in ''A. fischeri'' and other bacterial [[species]].[{{cite journal |last1=Fuqua |first1=W. Claiborne |last2=Winans |first2=Stephen C. |last3=Greenberg |first3=E. Peter |title=Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators |journal=Journal of Bacteriology |date=1994 |volume=176 |issue=2 |pages=269–275 |doi=10.1128/jb.176.2.269-275.1994 |pmid=8288518 |pmc=205046 |doi-access=free }}] |
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