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The [[flavonoid]] [[sterubin]] is the main active component of Yerba santa and is neuroprotective against multiple toxicities of the aging brain, including possibly [[Alzheimer's disease]].[{{cite journal | last1 = Wolfgang | first1 = F | last2 = Currais | first2 = A | last3 = Liang | first3 = Z | last4 = Pinto | first4 = A | last5 = Maher| first5 = P | title = Old age-associated phenotypic screening for Alzheimer's disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa | journal = Redox Biology | volume = 21 | article-number = 101089| date = February 2019 | pmid = 30594901| pmc = 6309122 | doi = 10.1016/j.redox.2018.101089 }}][{{cite journal |last1 = Liang | last2 = Maher| first2 = P |first1 = Z |title=Structural Requirements for the Neuroprotective and Anti-Inflammatory Activities of the Flavanone Sterubin |journal=Antioxidants |volume=11 |date=November 2022 | issue = 11|page=2197 |pmid=36358569 |pmc=9686938 |doi=10.3390/antiox11112197 | doi-access = free}}][{{cite web|title='Holy herb' (Yerba santa) identified as a potential treatment for Alzheimer's disease|url=https://www.news-medical.net/news/20190222/Holy-herb-(Yerba-santa)-identified-as-a-potential-treatment-for-Alzheimere28099s-disease.aspx|website=news-medical.net|date=22 February 2019|access-date=26 February 2019}}] |
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The [[flavonoid]] [[sterubin]] is the main active component of Yerba santa and is neuroprotective against multiple toxicities of the aging brain, including possibly [[Alzheimer's disease]].[{{cite journal | last1 = Wolfgang | first1 = F | last2 = Currais | first2 = A | last3 = Liang | first3 = Z | last4 = Pinto | first4 = A | last5 = Maher| first5 = P | title = Old age-associated phenotypic screening for Alzheimer's disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa | journal = Redox Biology | volume = 21 | article-number = 101089| date = February 2019 | pmid = 30594901| pmc = 6309122 | doi = 10.1016/j.redox.2018.101089 }}][{{cite journal |last1 = Liang | last2 = Maher| first2 = P |first1 = Z |title=Structural Requirements for the Neuroprotective and Anti-Inflammatory Activities of the Flavanone Sterubin |journal=Antioxidants |volume=11 |date=November 2022 | issue = 11|page=2197 |pmid=36358569 |pmc=9686938 |doi=10.3390/antiox11112197 | doi-access = free}}][{{cite web|title='Holy herb' (Yerba santa) identified as a potential treatment for Alzheimer's disease|url=https://www.news-medical.net/news/20190222/Holy-herb-(Yerba-santa)-identified-as-a-potential-treatment-for-Alzheimere28099s-disease.aspx|website=news-medical.net|date=22 February 2019|access-date=26 February 2019}}] |
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Flavonoid-rich yerba santa [[extract]] has been used as a [[dietary supplement]], especially in sports nutrition products,[{{Cite web |last= |date=2022-06-21 |title=Alpha Lion is getting back into the fat burning category back a big way with Apex Burn |url=https://www.stack3d.com/2022/06/alpha-lion-apex-burn.html |access-date=2026-04-23 |website=Stack3d |language=en}}] weight management products, as well as a natural, [[caffeine]]-free energizer. Pre-clinical and clinical research indicates benefits for weight-loss, fat-reduction, as well as enhanced hormonal balance and overall metabolic health.[{{Cite journal |last=Jo |first=Young-Hee |last2=Hong |first2=Eun-Mi |last3=Kim |first3=Sang-Back |last4=Kim |first4=Ju Gyeong |last5=Lee |first5=Sung-Jin |last6=Son |first6=Wansuk |last7=Ma |first7=Min-Jung |last8=Kim |first8=Sung Dae |last9=Choi |first9=Joo-Hee |last10=Seo |first10=Min-Soo |date=June 2025 |title=Therapeutic Potential of Santa Herba Extract in Obesity: Impact on Lipid Metabolism and Hormonal Balance |url=https://pubmed.ncbi.nlm.nih.gov/40535914 |journal=Food Science & Nutrition |volume=13 |issue=6 |pages= |doi=10.1002/fsn3.70479 |issn=2048-7177 |pmc=12173955 |pmid=40535914}}][{{Cite journal |last=Mödinger |first=Yvonne |last2=Schön |first2=Christiane |last3=Wilhelm |first3=Manfred |last4=Pickel |first4=Christina |last5=Grothe |first5=Torsten |date=2021-07-13 |title=A Food Supplement with Antioxidative Santa Herba Extract Modulates Energy Metabolism and Contributes to Weight Management |url=https://journals.sagepub.com/doi/full/10.1089/jmf.2021.0016 |journal=Journal of Medicinal Food |language=en |volume=24 |issue=11 |pages=1235–1242 |doi=10.1089/jmf.2021.0016 |issn=1096-620X}}] |
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